DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and abcc5

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	XP_012818083.1	Gene:	abcc5 / 100125060	XenbaseID:	XB-GENE-986260	Length:	1437	Species:	Xenopus tropicalis

Alignment Length:	1477	Identity:	457/1477 - (30%)
Similarity:	713/1477 - (48%)	Gaps:	253/1477 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KPTR-----KNPRQHANIISQLIFAWAIPLLYRGSRRG-LNTDDLTQCLKEDRSEQLGDRLEDQW 64
            ||.|     ::|..:|.:.|.:.|:|..|:.....::| |..:|:....|.:.|:....|||..|
Frog    90 KPFRITSKHQHPVDNAGLFSFMTFSWLTPMARIAYKKGELFFEDIWPLSKHESSDINSKRLEKLW 154

  Fly    65 FKELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLR 129
            .:|:  :.:...:..||:.::. |....:|..::|.           :|.||
Frog   155 LEEV--TEKGADESSLRSVVWH-FCRTRLIISIMCL-----------MLTQL------------- 192

  Fly   130 NIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNA 194
                                            :|..|.|...|||     ||..|...::..::.
Frog   193 --------------------------------AGFIGPAFVVKSL-----LEYTQQSSKDPGYSL 220

  Fly   195 TAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRL 259
            ..|.::|...:...|    ||.....|:               ...|:|:|.|..::.::|.|:|
Frog   221 LLVFALLMTEIVRSW----SLALTWALN---------------YRTGSRLRGAVLTMAFKKILKL 266

  Fly   260 SMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLL 324
              |...:...|.|||:.|:|..|:.........:...|:.|:|.  :|: |:   .|:|..|.|.
Frog   267 --KNIKEKSMGELINVCSSDGQRMFEAAAVGSLLAGGPIVAILG--MIY-NV---IILGPTGFLG 323

  Fly   325 KTV-----PVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRS 384
            ..|     |....:|::|:..|.:....||.||..|||::..|:.||||||.|.|...|.:.|.:
Frog   324 SAVFILFYPAMMFVSRLTAYFRRKCVSVTDERVQKMNEVLNYIKFIKMYAWVKAFSQNVQKIREN 388

  Fly   385 EIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYP 449
            |...:..|.|.:...:............:|.:...::|..:||...|:..:.:|.:.....: .|
Frog   389 ERSILERAGYFQSITVGIAPIVVVIASVLTFSVHMILGYDLTAAQAFTVVTVFNSMTFALKV-TP 452

  Fly   450 LAVSFGAEALVSLRRIQD-FLM------------------------------------------L 471
            .:|...:||.||:.|.:. |||                                          |
Frog   453 FSVKSLSEASVSMDRFKSLFLMEEVHMVKKKPSSPNLIIELKNATLAWDTTYASTQCSPKGTPKL 517

  Fly   472 EGREERTQGLTHKRDQEGGDSRAVTIK---------DINASWDIE---------KPQKTLQSINL 518
            :..::..:|...|...|...|:||..:         |.:.|.|.|         |.|:.|.||:|
Frog   518 KKGKKGVKGKKEKCSHEIEGSQAVLAEQKGHLLIDSDEHPSPDEETKELPVINVKLQRALYSIDL 582

  Fly   519 QIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEE 583
            .||||:|..:.|.||:||:|::..:||::.:::|.:.:.|..:|.||:.|:...::|:|||||:|
Frog   583 DIEKGKLIGICGSVGSGKTSLISAILGQMTLLEGSIAVSGSFAYVAQQAWILNATLRDNILFGKE 647

  Fly   584 FDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLS 648
            ||.:.|..|...|.|..|...|||||.|.:|||||:||||||.|||||||:|....||::|||||
Frog   648 FDEEEYNAVLNVCCLRPDLAILPNGDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLS 712

  Fly   649 AVDAHVGRHLFDEVIGPRGRLAQLKATRIL-VTHQVHFLSEADVIVIVDQGRILRQGTYQELINS 712
            |:|||||.|:|:..|     ...||:..|| :|||:.:|.:.|.::.:.:|.|..:||:::||..
Frog   713 ALDAHVGNHIFNSAI-----RKHLKSKTILFITHQLQYLVDCDDVIYMKEGCITERGTHEDLIKL 772

  Fly   713 DLDFA------RLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSV 771
            :.::|      :|.:.|..|:     .|....|. |||:.     |...|.|.|         ||
Frog   773 NGEYAAIFNNFQLGDAPHIEQ-----MNLKKNLK-NSLKK-----PLEKGNKAG---------SV 817

  Fly   772 HGSKSLDSTQLDDNVDEDDLAEAQASG-GISPRVWYEYFHAGSTLLS----FSFMVFVMVMSQVV 831
            ...|::..       :|..|.:.:..| |..|  |..|   |:.:.|    |:|::.:.:.  |:
Frog   818 KKEKTVKK-------EEGQLMQLEEKGKGSVP--WSVY---GAYIQSAGGPFAFLIIMTLF--VL 868

  Fly   832 CSSSDFFANIWTQQEHQRSQGEAT--------------------FSTFECMYIYGALIIAVVIMT 876
            ...|..|:|.|.....::..|..|                    |.|    .||...::.::::.
Frog   869 NVGSTAFSNWWLSYWIKQGSGNTTVVVHNETVVSNSMKDNPHVLFYT----AIYALSMVVMLLLK 929

  Fly   877 TFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFI 941
            ..||.:|.|..:.||..|||.:|..||.:.|:||||||:||:||||||||..:|..||.....|:
Frog   930 AVRGIVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRVLNRFSKDMDEVDVRLPFQAEMFV 994

  Fly   942 QIALVMFGILIVIGILNP---VLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSA 1003
            |..:::|..|.||..:.|   |.|..::|:..:..::.::::|   :|||||.|.:||..||:::
Frog   995 QNVILVFFCLGVISFVFPWFLVAVGPLVVLFTILHVVSRVFIR---ELKRLENITQSPFLSHITS 1056

  Fly  1004 SLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISS 1068
            |:.||..|.:....:.....:..|.|.:.:.:.|.......|.:.||.:|...:|:.....::..
Frog  1057 SIQGLTTIHAYSKGNEFLLRYQELLDNNQAPFYLFNCAMRWLAIRLDVISVSLITTTGLMIVLMH 1121

  Fly  1069 ETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTE---LEQEPALGEKTPPQQ 1130
            ........|||::.|:.|||:.|:.||..:|:..:.|||||:..|.:   ||....:..|.||..
Frog  1122 GNISPAYAGLAMSYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLALEAPARIKNKAPPAD 1186

  Fly  1131 WPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIEGE-I 1194
            ||..|:::|.|...||..|...||:.::.||:...|:|||||||:||:||..|||||..:.|. |
Frog  1187 WPQEGEIKFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKTSLGMALFRLVELSGGCI 1251

  Fly  1195 FIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIP--- 1256
            .|||::...|.|..||:::|||||:|||||.|:|.|||||.:|::.::|.|||...:::.:.
Frog  1252 KIDGVKISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFSQYSEEQIWDALERTHMKECVAQLP 1316

  Fly  1257 -GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTV 1320
             .|:..|.|.|.|||||:|||:|:||.:||..|:|:||||||.:|.:||.|||.|||..|.:||:
Frog  1317 LKLETEVLENGENFSVGERQLMCIARVLLRRCKILILDEATAAMDTETDLLIQETIREAFAECTM 1381

  Fly  1321 LTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367
            ||:|||||||:..|||:|:..|..:|:|.|..||.........|..|
Frog  1382 LTIAHRLHTVLSCDRIMVLAQGQVMEYDTPSALLSNENTRFFSMFAA 1428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	454/1472 (31%)
		ABC_membrane	214..441	CDD:294371	59/231 (26%)
		ABCC_MRP_domain1	495..699	CDD:213217	94/222 (42%)
		ABC_membrane	863..1088	CDD:294371	72/227 (32%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	111/219 (51%)
abcc5	XP_012818083.1	PLN03130	101..1425	CDD:215595	452/1461 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930