DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and abcc1

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	XP_001341895.3	Gene:	abcc1 / 100002010	ZFINID:	ZDB-GENE-050517-15	Length:	1518	Species:	Danio rerio

Alignment Length:	1456	Identity:	474/1456 - (32%)
Similarity:	726/1456 - (49%)	Gaps:	234/1456 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKEL-- 68
            |.:...|...|:.:|::.|.|...|:.:|.:|.|...||.....||:||::..:|..:|.:|.
Zfish   203 KDSNPCPESGASFLSKITFWWITGLMVKGYKRPLEEKDLWSLNNEDKSERVVPQLVRRWDQECVK 267

  Fly    69 ------------ERSHRKKQK---------------------PHLRNALFRCFLGP-TIINGLIC 99
                        :||.|.::|                     |.|..||.|.| || .:::.|..
Zfish   268 VKRPVDKTLYSPKRSTRGEKKDGQPVEESEILLAKALQKTGEPSLFFALCRTF-GPYFLVSSLYK 331

  Fly   100 FIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGS 164
            .|:.|:..:.|.:| :|||.|            |||                          |.:
Zfish   332 IIHDVLMFVGPEIL-RLLILF------------VND--------------------------SSA 357

  Fly   165 PGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFL 229
            |                                          .|:      .....:.||.|..
Zfish   358 P------------------------------------------TWH------GYFYTALLFVCTC 374

  Fly   230 LHHVDLRQR-----LMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIF 289
            |..:.|::.     :.|.|:|.|....:|||.|.::......:..|.::||:|.|..|......:
Zfish   375 LQTLILQKYFHVCFVTGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITY 439

  Fly   290 MHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGI 354
            ::.||..|||.:|..|.:|.|:|...:.||..::| .||:...::..|...::...:..|.|:.:
Zfish   440 INMIWSAPLQVILALYFLWQNLGASVLAGVAVMVL-MVPLNAVIAMKTKTYQVAQMKSKDNRIKL 503

  Fly   355 MNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAA 419
            |||::.||:|:|:||||..|:..|:..|.||::.::..:||......|.|.........|.|...
Zfish   504 MNEVLNGIKVLKLYAWELAFKGKVSAIRESELRVLKKMAYLGAISTFTWVCAPFLVALSTFAVYV 568

  Fly   420 LMGQT--ITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLT 482
            |:.:.  :.|...|.:.:.:|||:....: .|:.:|...:|.||::|::.||..|..::...
Zfish   569 LVDENNILDAQKAFVSLALFNILRFPLNM-LPMVISSMVQASVSMQRLRVFLSHEELDDDNV--- 629

  Fly   483 HKRDQEGGDSRAVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGEL 547
             :|....|...::.|.|...||..:.| .||:.||:.|.:|.|.||:|.||:||||:|..||||:
Zfish   630 -ERPAISGTPDSIRIADGAFSWSKDDP-PTLKRINVSIPEGALVAVVGHVGSGKSSLLSALLGEM 692

  Fly   548 PVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTL 612
            ...:|.|.|:|.::|..|:.|:...::::|||||.|.....||:|...|||..|.:.||.||.|.
Zfish   693 HKQEGSVSIKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACALLPDLEILPGGDTTE 757

  Fly   613 VGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRI 677
            :||:|.:|||||:.|:|:|||||....:||:||||||||||||:|:|::||||:|.|.  ..||:
Zfish   758 IGEKGVNLSGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGLLQ--GRTRV 820

  Fly   678 LVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLE--RPKEEEEGENSRNQTSPLS 740
            ||||.:.||.:||:|:::..|.|...|:|.||:.....||..|.  ...|:||||.|.....|..
Zfish   821 LVTHGLSFLPQADLILVMVDGEITEMGSYTELLGRQGAFAEFLRTYTNTEQEEGEESLGDAVPRK 885

  Fly   741 VNSLESDDEDIPFIDGVKDG--YQQLRKQSSSVHGS---KSLDSTQLDDNVDEDDLAEAQAS--- 797
                           |:::|  ...||:...|::.:   |:...|:.:|:........|:||
Zfish   886 ---------------GLENGGPAALLRQSQISLNATGAGKTTQKTEANDDAAATKTKSAEASRLT 935

  Fly   798 -------GGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIW--------TQQEH 847
                   |.:...|::||..|....||. |.:|:.....:....|:::.::|        ||.:.
Zfish   936 EADKANTGRVKLSVFWEYMKAIGLPLSI-FSIFLFFCHHLSSLGSNYWLSLWTDDPVVNNTQPKR 999

  Fly   848 QRSQGEATFSTFECMYIYGAL-------IIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHA 905
            :...|           :||||       :....:..:..|.|       ||:.||..|...:|.:
Zfish  1000 EMRLG-----------VYGALGISQGIAVFCYSVSVSVGGIL-------ASRYLHQTMLYNVLRS 1046

  Fly   906 TMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAV 970
            .|.||:.||||.::|||:|:...||.::|..      |.:.|..:..|:|....:|:|..||..:
Zfish  1047 PMSFFERTPSGNLVNRFAKETDTIDSVIPSI------IKMFMGSMFNVLGSCAVILIATPLVAII 1105

  Fly   971 VDVL------ILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQD 1029
            :..|      :.:.|:..|:.:||||.:.||||::|.:.:|.|.::||:...|....||.|...|
Zfish  1106 IPPLGLLYFFVQRFYVASSRQMKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIKESDGRVD 1170

  Fly  1030 VHSSVWQLTMAVNTTLGLWLDCV-SCIFLTSVTFS--FIISSETTYS-GNVGLAIAQAMILTGMV 1090
            .:...:..::..|..|.:.|:.| :||    |||:  |.:.:....| |.:||:|:.|:.:|..:
Zfish  1171 HNQKAYFPSIVANRWLAVRLEFVGNCI----VTFAALFAVMARNNLSPGIMGLSISYALQVTASL 1231

  Fly  1091 QYGVRQVAESLQQMTSVERVLQY--TELEQEPALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPV 1153
            .:.||..:|....:.:||||.:|  ||.|.|..|.....|..|||.|.:|......||..:....
Zfish  1232 NWLVRMSSELETNIVAVERVKEYGDTEKEAEWKLENSNLPPGWPTAGHIEIHKFGLRYREDLELA 1296

  Fly  1154 LRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLEILRTRISIIP 1217
            :.::::.|..|.|||||||||||||||...|||:.. .||||.|||:....:.|..||:||:|||
Zfish  1297 ICDISVNIAGGEKVGIVGRTGAGKSSLTLGLFRIIEAAEGEIRIDGVNIADLGLHELRSRITIIP 1361

  Fly  1218 QDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIPG----LDYMVTERGGNFSVGQRQLLC 1278
            |||||||.::|.|||||:.|||.|:|.:||...|:..:.|    |::..:|.|.|.|:|||||:|
Zfish  1362 QDPVLFSGSLRMNLDPFDGYTDEEVWRSLELAHLKTFVSGLPDKLNHECSEGGENLSLGQRQLVC 1426

  Fly  1279 LARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGV 1343
            ||||:||..|:||||||||.||.:||.|||.|||.:|:.|||||:||||:|:||..|::|:|.|.
Zfish  1427 LARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGQ 1491

  Fly  1344 AVEFDVPYLLLKKSQGHLRQMVEATG 1369
            ..|||.|..|:.| :|...:|.:.:|
Zfish  1492 MAEFDSPSNLIAK-KGIFYKMAKDSG 1516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	472/1449 (33%)
		ABC_membrane	214..441	CDD:294371	64/233 (27%)
		ABCC_MRP_domain1	495..699	CDD:213217	99/203 (49%)
		ABC_membrane	863..1088	CDD:294371	71/241 (29%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	117/219 (53%)
abcc1	XP_001341895.3	MRP_assoc_pro	7..1517	CDD:188098	474/1456 (33%)
		ABC_membrane	331..595	CDD:279056	79/351 (23%)
		ABCC_MRP_domain1	641..842	CDD:213217	99/203 (49%)
		ABC_membrane	966..1231	CDD:279056	78/292 (27%)
		ABCC_MRP_domain2	1278..1498	CDD:213211	117/219 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830