DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pp1alpha-96A and PPP3CC

DIOPT Version :9

Sequence 1:NP_001262919.1 Gene:Pp1alpha-96A / 42922 FlyBaseID:FBgn0003134 Length:327 Species:Drosophila melanogaster
Sequence 2:NP_001230903.1 Gene:PPP3CC / 5533 HGNCID:9316 Length:521 Species:Homo sapiens


Alignment Length:306 Identity:111/306 - (36%)
Similarity:175/306 - (57%) Gaps:33/306 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 KNVQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFL 88
            |..:|.|.....:......|...:..::|::||:.:|||||||::||::|||.||.|..:.||||
Human    48 KEGRLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFL 112

  Fly    89 GDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASINRIYGFYDECKRRYTIKLWKTFTDC 153
            |||||||..|:|.:..|.:.||.:.:..|||||||||..:...:.|..||:.:|:.:::....:.
Human   113 GDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMET 177

  Fly   154 FNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGEND 218
            |:|||:||:::::..|.|||:||:::|::.||::.|.|:.|..|.:||||||||.:|   :|...
Human   178 FDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSED---YGNEK 239

  Fly   219 ----------RGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQ------LVTLFSA 267
                      ||.|:.:....|.:|||.:....|.|||:..:.||..:.|.|      |:|:|||
Human   240 TLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSA 304

  Fly   268 PNYCGEFDNAGAMMSVDDTLM------CSFQILKPADKRRFVYPNF 307
            |||...::|..|::..::.:|      ||        ...:..|||
Human   305 PNYLDVYNNKAAVLKYENNVMNIRQFNCS--------PHPYWLPNF 342

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pp1alpha-96ANP_001262919.1 MPP_PP1_PPKL 6..296 CDD:277359 108/293 (37%)
PPP3CCNP_001230903.1 MPP_PP2B 37..341 CDD:277361 108/303 (36%)
Catalytic. /evidence=ECO:0000305 52..343 110/302 (36%)
PP2Ac 54..325 CDD:197547 103/273 (38%)
SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209 303..307 3/3 (100%)
Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:P16298 344..366
Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P16298 395..409
Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298 410..417
Autoinhibitory domain. /evidence=ECO:0000250|UniProtKB:P16298 468..490
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 480..521
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0639
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53795
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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