DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pp1alpha-96A and PPP3CB

DIOPT Version :9

Sequence 1:	NP_001262919.1	Gene:	Pp1alpha-96A / 42922	FlyBaseID:	FBgn0003134	Length:	327	Species:	Drosophila melanogaster
Sequence 2:	NP_001135825.1	Gene:	PPP3CB / 5532	HGNCID:	9315	Length:	525	Species:	Homo sapiens

Alignment Length:	329	Identity:	115/329 - (34%)
Similarity:	180/329 - (54%)	Gaps:	41/329 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDIMNIDSIISRLLEVRGARPGKNVQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHG 65
            :..|..:|.:.:.|:        |..::.|.....:..:...|...:..::|:|||:.:||||||
Human    46 LDGIPRVDVLKNHLV--------KEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHG 102

  Fly    66 QYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASINR 130
            |::||::|||.||.|..:.|||||||||||..|:|.:..|...||.|....|||||||||..:..
Human   103 QFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTE 167

  Fly   131 IYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPD 195
            .:.|..|||.:|:.::::...:.|:.||:||:::::..|.||||||::.:::.|||:.|..:.|.
Human   168 YFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPA 232

  Fly   196 QGLLCDLLWSDPDKDTMGWGEND----------RGVSFTFGAEVVGKFLQKHEFDLICRAHQVVE 250
            .|.:||||||||.:|   :|...          ||.|:.:....|.:|||.:....|.|||:..:
Human   233 FGPMCDLLWSDPSED---FGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQD 294

  Fly   251 DGYEFFAKRQ------LVTLFSAPNYCGEFDNAGAMMSVDDTLM------CSFQILKPADKRRFV 303
            .||..:.|.|      |:|:||||||...::|..|::..::.:|      ||        ...:.
Human   295 AGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCS--------PHPYW 351

  Fly   304 YPNF 307
            .|||
Human   352 LPNF 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp1alpha-96A	NP_001262919.1	MPP_PP1_PPKL	6..296	CDD:277359	111/311 (36%)
PPP3CB	NP_001135825.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		MPP_PP2B	50..354	CDD:277361	111/322 (34%)
		Catalytic. /evidence=ECO:0000305	65..356		111/302 (37%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	316..320		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000269\|PubMed:26794871	357..379
		Calmodulin-binding. /evidence=ECO:0000269\|PubMed:26794871	402..416
		Autoinhibitory segment. /evidence=ECO:0000269\|PubMed:26794871	417..424
		Autoinhibitory domain. /evidence=ECO:0000269\|PubMed:26794871	475..497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820