DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pp1alpha-96A and PPP3CA

DIOPT Version :9

Sequence 1:	NP_001262919.1	Gene:	Pp1alpha-96A / 42922	FlyBaseID:	FBgn0003134	Length:	327	Species:	Drosophila melanogaster
Sequence 2:	NP_000935.1	Gene:	PPP3CA / 5530	HGNCID:	9314	Length:	521	Species:	Homo sapiens

Alignment Length:	306	Identity:	115/306 - (37%)
Similarity:	176/306 - (57%)	Gaps:	33/306 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KNVQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFL 88
            |..:|.||....:..:...|...:..||:::||:.:|||||||::||::|||.||.|..:.||||
Human    52 KEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFL 116

  Fly    89 GDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASINRIYGFYDECKRRYTIKLWKTFTDC 153
            |||||||..|:|.:..|.|.||.|.:..|||||||||..:...:.|..|||.:|:.:::....|.
Human   117 GDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDA 181

  Fly   154 FNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGEND 218
            |:|||:||:::::..|.||||||::::::.||::.|..:.|..|.:||:|||||.:|   :|...
Human   182 FDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLED---FGNEK 243

  Fly   219 ----------RGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQ------LVTLFSA 267
                      ||.|:.:....|.:|||.:....|.|||:..:.||..:.|.|      |:|:|||
Human   244 TQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSA 308

  Fly   268 PNYCGEFDNAGAMMSVDDTLM------CSFQILKPADKRRFVYPNF 307
            |||...::|..|::..::.:|      ||        ...:..|||
Human   309 PNYLDVYNNKAAVLKYENNVMNIRQFNCS--------PHPYWLPNF 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp1alpha-96A	NP_001262919.1	MPP_PP1_PPKL	6..296	CDD:277359	112/293 (38%)
PPP3CA	NP_000935.1	MPP_PP2B	41..345	CDD:277361	112/303 (37%)
		Catalytic. /evidence=ECO:0000305	56..340		111/294 (38%)
		SAPNY motif. /evidence=ECO:0000305\|PubMed:26248042	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269\|PubMed:17498738, ECO:0000269\|PubMed:17502104, ECO:0000269\|PubMed:22343722, ECO:0000269\|PubMed:23468591, ECO:0000269\|PubMed:26248042	327..336		1/8 (13%)
		Calcineurin B binding. /evidence=ECO:0000269\|PubMed:12218175, ECO:0000269\|PubMed:12357034, ECO:0000269\|PubMed:17498738, ECO:0000269\|PubMed:23468591, ECO:0000269\|PubMed:27974827, ECO:0000269\|PubMed:8524402	341..369		3/6 (50%)
		Calmodulin-binding. /evidence=ECO:0000269\|PubMed:18384083, ECO:0000269\|PubMed:19404396, ECO:0000269\|PubMed:25144868, ECO:0000269\|Ref.31	392..406
		Autoinhibitory segment. /evidence=ECO:0000250\|UniProtKB:P16298	407..414
		Autoinhibitory domain. /evidence=ECO:0000269\|PubMed:8524402	465..487
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..521
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820