DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13617 and Dzip1

DIOPT Version :9

Sequence 1:	NP_001262918.1	Gene:	CG13617 / 42921	FlyBaseID:	FBgn0039201	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_080219.2	Gene:	Dzip1 / 66573	MGIID:	1914311	Length:	852	Species:	Mus musculus

Alignment Length:	823	Identity:	161/823 - (19%)
Similarity:	275/823 - (33%)	Gaps:	253/823 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GPL------------DWRLMGSYETERI--------LREQNF-----ELVDKALTHLSEAPLGTV 63
            |||            |||.:.:.:.:::        |:|...     :|.|:...|....
Mouse    38 GPLPFFQFRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSG----- 97

  Fly    64 LETHILDSGIAKYFVMSQYAIQYLMCCRTYLDECVTDLKEAHTTAQEEIATLRKSLSESNNEVVQ 128
                 :|..:.|...::|..|:|||..:.:|...:..::|          .||.||.:.......
Mouse    98 -----VDPVLLKLIRLAQLTIEYLMHSQEFLTSQLNLVEE----------RLRLSLLDYEQSKQL 147

  Fly   129 LHKRITQIEAIRE--------------------VVYPCHLCTKNFISNEALNVHIGRKHRVASPP 173
            |.|:..:|:.::|                    ..|.||.|.|.|::...|..||.|:|
Mouse   148 LTKQAGEIKLLKEECKRRKKMLSTQQLMIEAKASYYQCHFCDKAFMNQAFLQSHIQRRH------ 206

  Fly   174 SLTSATGKEKDRDKATDVHL-----INTIKMELEIKQLKERLNAAERNIKERSTGSKRVSPRQEQ 233
                          ..|.||     ..|.:::.||..|||:|......::.          .|..
Mouse   207 --------------TEDSHLEYNTKAQTDRLQKEIDMLKEQLQLTRSQLES----------AQHS 247

  Fly   234 RHVGIQSNLAEPKEKDEDSGEARQSEASERKEQLTGLAERLSNFEEWQTQLKQSNEQFIQDINKR 298
            ..|....:....|.|:||..:.......|.||:|....|::..             .|:::. |.
Mouse   248 HAVRFSKDYEMQKSKEEDFLKLFDRWKEEEKEKLLEEMEKVKG-------------MFMREF-KE 298

  Fly   299 LEGLSHALE-QSKQASASTPPLEDRVAT------------PCLEDLERILTEKVAEIGKVSAHRL 350
            |...:.||| |..:...|...::..:.|            ||.:|.:.:|     ::....|.:.
Mouse   299 LTSKNSALEYQLLEIQKSNIQIKSNIGTLRDVTELREDHLPCPQDFQNML-----QLLDSQASKW 358

  Fly   351 EEVVYHLEEGYKEKLGALERELKQLSVQKVQPEPVQTVPVASKIPKPVVRKEETNIDRIRKQVES 415
            .:....|.|.:.::.|.|      ||                            :|:::|    |
Mouse   359 TDRFQVLNEEHSKEKGQL------LS----------------------------HIEKLR----S 385

  Fly   416 EFLKQKHDDDTY---SIEEAPRKGSEKPFPQLVTQVQVVEK--EQPSAGSSDSNPT----YTKSP 471
            ..:|....|:.:   .:||..:|..|:. ..:::|.|.:.:  .:|.:..|:...|    .|..|
Mouse   386 SMMKDLSADNVFYKRRVEELGQKLQEQN-ELIISQKQQIREFASKPYSSISELKGTPLTRQTLEP 449

  Fly   472 REPAPNKQETKEATDVSDSLSQ-----------------EETENEEERSLTEEEGTDVPTSGSEA 519
            :..||....|..||...|..|.                 ||..:|||:....|:..:..||..:.
Mouse   450 KSAAPTTPMTASATQNLDGASSLTMVHEQVFSSHILEPIEELSSEEEKGRENEQKLNKKTSLRKP 514

  Fly   520 AREDPTPKTIKPSGRIIKSPQKPLTRKDARKMVNRKLMSHGFDMKSKGISHNSLKRVNSELTEHR 584
            :...|:|:.:               |.:..:.:..||.|.|.....:||....|.|....:...|
Mouse   515 SSTSPSPQEL---------------RTNLERELGNKLRSFGIGANIQGIPCEILNRSLKAMQVAR 564

  Fly   585 NKLKLQHPHFYATRNRIRKFVEKLCSAKFSERAEMLL-KHKSPL----------KPMEVPGKGIP 638
            :.|..|.|..    .:||:.:|.....|..|:..:.. :|..|.          |..::|.|..|
Mouse   565 HDLAKQMPDI----QQIRESLEHQLICKMEEKVSLSSDRHHVPSMTTFPPEEVPKATQLPHKSRP 625

  Fly   639 ----RSAISEKSEEDIASSQGEE--------QTDEQTDSSEQQTRSPSPQRLVSRDFKARLEEIL 691
                |:..::|..........:|        .|.....|||::   |..:.|:    .|.|....
Mouse   626 LVRQRTVFTDKVSVPKLKKNTKESHFLRRFPSTKTPPFSSEEE---PDEEDLL----HAYLSPDS 683

  Fly   692 VKPAATIRGASKSSLSSRPVPLPRKRVMFNTT-EDGKSFNDSD 733
            :..|||  ...|||:|.    ..:..|..:|. .:|...:|||
Mouse   684 LATAAT--QPPKSSMSH----FGKSAVKSDTDWTEGSEMDDSD 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13617	NP_001262918.1	Dzip-like_N	16..133	CDD:290529	26/133 (20%)
Dzip1	NP_080219.2	Dzip-like_N	43..163	CDD:372735	25/139 (18%)
		SMC_prok_B	104..>438	CDD:274008	81/431 (19%)
		C2H2 Zn finger	183..207	CDD:275369	11/43 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	434..463		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..524		10/34 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..623		4/25 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	648..672		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..726		13/42 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	772..837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28IYV
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	61	1.000	Inparanoid score	I5393
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003708
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21502
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5355
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	6.040