Protein Alignment CG13617 and DZIP1

DIOPT Version :9

• Sequence 1: NP_001262918.1
• Gene: CG13617 / 42921
• FlyBaseID: FBgn0039201
• Length: 737
• Species: Drosophila melanogaster
• Sequence 2: XP_006719979.1
• Gene: DZIP1 / 22873
• HGNCID: 20908
• Length: 932
• Species: Homo sapiens
• Alignment Length: 805
• Identity: 170/805 - (21%)
• Similarity: 290/805 - (36%)
• Gaps: 211/805 - (26%)

  Fly    24 GPL------------DWRLMGSYETERI--------LREQNF-----ELVDKALTHLSEAPLGTV 63
            |||            |||.:.:.:.:::        |:|...     :|.|:...|....
Human    99 GPLPFFQFRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSG----- 158

  Fly    64 LETHILDSGIAKYFVMSQYAIQYLMCCRTYLDECVTDLKE----AHTTAQEEIATLRKSLSE--S 122
                 :|..:.|...::|:.|:||:..:.:|...:..|:|    :|...::....|.|...|  :
Human   159 -----VDPVLLKLIRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKT 218

  Fly   123 NNEVVQLHKRI--TQ---IEAIREVVYPCHLCTKNFISNEALNVHIGRKHRVASPPSLTSATGKE 182
            ..|..:..|::  ||   ||| :...|.||.|.|.|::...|..||.|:|         :.....
Human   219 LKEECKRRKKMISTQQLMIEA-KANYYQCHFCDKAFMNQAFLQSHIQRRH---------TEENSH 273

  Fly   183 KDRDKATDVHLINTIKMELEIKQLKERLNAAERNIKERSTGSK-RVSPRQEQRHVGIQSNLAEPK 246
            .:..|...:.     |:..||..|||.|......::.....|. |.|...|.:           |
Human   274 FEYQKNAQIE-----KLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQ-----------K 322

  Fly   247 EKDEDSGEARQSEASERKEQLTGLAERLSNFEEWQTQLKQSNEQFIQDINKRLEGLSHALE-QSK 310
            .|:||..:.......|.||:|.             .::::..|.|:::. |.|...:.||| |..
Human   323 TKEEDFLKLFDRWKEEEKEKLV-------------DEMEKVKEMFMKEF-KELTSKNSALEYQLS 373

  Fly   311 QASASTPPLEDRVAT------------PCLEDLERILTEKVAEIGKVSAHRLEEVVYHLEEGYKE 363
            :...|...::..:.|            |..:|...::....::..|.:|.     |..:.:.:|:
Human   374 EIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTAR-----VQAIHQEHKK 433

  Fly   364 KLGALERELKQLSVQKVQPEPVQTVPVASKIPKPVVRKEETN--IDRIRKQVESEFLKQKHDDDT 426
            :.|.|...:::|....:.......|....:|.:...|.:|.|  |...|:|::         |.|
Human   434 EKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIK---------DFT 489

  Fly   427 YSIEEAPRKGSEKPFPQLVTQVQVVEKEQPSAGSS-DSNPTYTKSP-REPAPNKQETKEA----- 484
            .:    |.....:|            |..|.|..: :|.|.....| ..||.:..|||.:
Human   490 CN----PLNSISEP------------KGNPLAWQAFESQPAAPAVPMNAPALHTLETKSSLPMVH 538

  Fly   485 --------TDVSDSLSQEETENEEERSLTEEEGTDVPTSGSEAAREDPTPKTIKPSGRIIKSPQK 541
                    .:..:.||:||...|.|:.|..              .:....|.:|.:..:.|.
Human   539 EQAFSSHILEPIEELSEEEKGRENEQKLNN--------------NKMHLRKALKSNSSLTKG--- 586

  Fly   542 PLTRKDARKMVNRKLMSH----GFDMKSKGISHNSLKRVNSELTEHRNKLKLQHPHFYATRNRIR 602
                  .|.||.:.||..    |.:...:|||.:.|.||...:...|:|.:.:.|:|:    :||
Human   587 ------LRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFH----QIR 641

  Fly   603 KFVEKLCSAKFSERAEMLLKHKSPLKPMEVPGKG-IPRSAISEKSEEDIASSQGEEQTDEQTDSS 666
            :|:|...|.|..|:| :|...:..:..|:....| :|:.         |.......|...|...|
Human   642 EFLEHQVSCKIEEKA-LLSSDQCSVSQMDTLSTGEVPKM---------IQLPSKNRQLIRQKAVS 696

  Fly   667 EQQTRSPSPQRLVSRD-FKARLEEILVKPAAT---------IRG-ASKSSLSSRPVPLPRKRVMF 720
            ..:|..|..::.|..| |..:...|...|.::         ||. ||...|   |||.|:.:..|
Human   697 TDRTSVPKIKKNVMEDPFPRKSSTITTPPFSSEEEQEDDDLIRAYASPGPL---PVPPPQNKGSF 758

  Fly   721 --NTTE------DGKSFNDSDDNLK 737
              ||.:      :|....|:||:.|
Human   759 GKNTVKSDADGTEGSEIEDTDDSPK 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13617	NP_001262918.1	Dzip-like_N	16..133	CDD:290529	26/139 (19%)
DZIP1	XP_006719979.1	C2H2 Zn finger	246..267	CDD:275368	9/20 (45%)
		iSH2_PI3K_IA_R	273..402	CDD:304922	30/158 (19%)
		Dzip-like_N	104..224	CDD:290529	22/129 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	69	1.000	Inparanoid score	I5330
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003708
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21502
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5355
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.180