DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13617 and DZIP1L

DIOPT Version :9

Sequence 1:	NP_001262918.1	Gene:	CG13617 / 42921	FlyBaseID:	FBgn0039201	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	XP_011510820.1	Gene:	DZIP1L / 199221	HGNCID:	26551	Length:	806	Species:	Homo sapiens

Alignment Length:	740	Identity:	158/740 - (21%)
Similarity:	283/740 - (38%)	Gaps:	210/740 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FKLRQYRDGPLDWRLMGSYETERILREQNFELVDKALTHLSEAPLGTVLETHI---LDSGIAKYF 77
            ||. |.|...:|||.:.:.:.:|:.||.:...:.:.:..::...|...:.:..   :|..:.|..
Human    52 FKF-QPRHDSMDWRRISTLDVDRVARELDVATLQENIAGITFCNLDREVCSRCGQPVDPALLKVL 115

  Fly    78 VMSQYAIQYLMCCRTYLDECVTDLKEAHTTAQEEIATLRKSLSESNNEVVQLHKRITQIEAIRE- 141
            .::|..|:||:.|:..|...|..|:          |.|:.||.:......:|.::..:::.:||
Human   116 RLAQLIIEYLLHCQDCLSASVAQLE----------ARLQTSLGQQQRGQQELGRQADELKGVREE 170

  Fly   142 ---------------------VVYPCHLCTKNFISNEALNVHIGRKHRVASPPSLTSATGKEKDR 185
                                 ..:.||||.|.|::...|..||.|:|      :..:..||:|
Human   171 SRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRH------AGVAEGGKQK-- 227

  Fly   186 DKATDVHLINTIKMELEIKQLKERLNAAERNIKERSTGSKRVSPRQEQRHVGIQSNLAEPKEKDE 250
                        |.|..::::.|.|.|     |.:.|..:..:.|:.:|    |..|.|.:...:
Human   228 ------------KQEQPVEEVLEELRA-----KLKWTQGELEAQREAER----QRQLQEAELIHQ 271

  Fly   251 DSGEARQSEASERKEQ----LTGLAERLSN--FEEWQTQLKQSNEQFIQDINKRLEGL-SHALEQ 308
            ...||:: |..:.|||    |.|..::|..  ::|::...||::     .:.::|..| ||::.:
Human   272 REIEAKK-EFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNS-----TLEEKLRALQSHSVME 330

  Fly   309 SKQASASTPPLEDRVATPCLEDLERI--LTEKVAEIGKVSAHRLEEVVYHLEEGYKEKLGALERE 371
            ||..|     |.|..:...|.....:  |.|| .||.|....|..:.::  ||...||     :|
Human   331 SKLGS-----LRDEESEEWLRQARELQALREK-TEIQKTEWKRKVKELH--EEHMAEK-----KE 382

  Fly   372 LKQLSVQKVQPEPVQTVPVASKIPKPVVRKEETNIDRIRKQVESEFLKQKHDDDTYSIEEAPRKG 436
            |::.: |::|..       .|:..|....:.:..|..:|.|::               |:|....
Human   383 LQEEN-QRLQAS-------LSQDQKKAAAQSQCQISTLRAQLQ---------------EQARIIA 424

  Fly   437 SEKPFPQLVT--QVQVVEKEQPSAGSSDSNPTYTKSPREPAPNKQETKEATDVSDSLSQEETENE 499
            |::...|.::  :|:.:.| .|.|..::.:     ||.|                  ..|::::|
Human   425 SQEEMIQSLSLRKVEGIHK-VPKAVDTEED-----SPEE------------------EMEDSQDE 465

  Fly   500 EERSLTEEEGTDVPTSGSEAAREDPT-PKTIKPSGRIIKSPQKPLTRKDARKMVNRKLMSHGFDM 563
            :.:.|.             |.|.:|| .|..:|   |::.            .:..||.|.|...
Human   466 QHKVLA-------------ALRRNPTLLKHFRP---ILED------------TLEEKLESMGIRK 502

  Fly   564 KSKGISHNSLKRVNSELTEHRNKLKLQHPHFYATRNRIRKFVEKLCSAKFSERAEMLLKHKSPLK 628
            .:||||..:|:.:.|.|...|.:             :.|||.|.|     |.|.:::.:..|..|
Human   503 DAKGISIQTLRHLESLLRVQREQ-------------KARKFSEFL-----SLRGKLVKEVTSRAK 549

  Fly   629 PMEVPGKGIPRSAISEKSEEDIASSQGEEQTDEQTDSSEQQTRSPSPQRLVSRDFKARLEEILVK 693
                           |:.|.....||.:.|...::..|...||...|:   :|..:..|.....:
Human   550 ---------------ERQENGAVVSQPDGQPSVKSQQSTLVTREAQPK---TRTLQVALPSTPAE 596

  Fly   694 PAATIR---GASKSSLSSRPVPLPR 715
            |....|   |:..|||:....|.||
Human   597 PPPPTRQSHGSHGSSLTQVSAPAPR 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13617	NP_001262918.1	Dzip-like_N	16..133	CDD:290529	26/119 (22%)
DZIP1L	XP_011510820.1	Dzip-like_N	52..172	CDD:290529	28/130 (22%)
DZIP1L	XP_011510820.1	DUF4795	233..403	CDD:292662	49/205 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28IYV
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	69	1.000	Inparanoid score	I5330
Isobase	1	0.950	-	0	Normalized mean entropy	S8157
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003708
OrthoInspector	1	1.000	-	-		oto91780
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21502
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5355
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.990