DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta2 and HTR3B

DIOPT Version :9

Sequence 1:NP_524483.1 Gene:nAChRbeta2 / 42920 FlyBaseID:FBgn0004118 Length:519 Species:Drosophila melanogaster
Sequence 2:NP_006019.1 Gene:HTR3B / 9177 HGNCID:5298 Length:441 Species:Homo sapiens


Alignment Length:484 Identity:111/484 - (22%)
Similarity:207/484 - (42%) Gaps:79/484 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 WSLLCVFLLVPLANSTAPISFEANPDTKRLY---DDLLSNYNRLIRPVVNNTETLTVWLGLKLSQ 65
            |:.:.|...: ||..|      .:|....||   ..||..|::.:|||.|.|:..||:|.|.:..
Human    10 WACILVAAGI-LATDT------HHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHA 67

  Fly    66 LIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTL 130
            :::|:.:||::.|::|.::.|.|..|.|:...:..:.::.:|...||.|||::      |..|.:
Human    68 ILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII------NEFVDI 126

  Fly   131 MTKATLKY-----TGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQI 190
            .....|.|     :|.:....|....|:|.:....||:|.|.|.:.|.|..:....|||..|   
Human   127 ERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFL--- 188

  Fly   191 PGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVP 255
              .:...:..|...|....||::|.|.:|.:  ....:...|:.|.|.:.|||..|.|.|:|::|
Human   189 --RSPEDIQHDKKAFLNDSEWELLSVSSTYS--ILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIP 249

  Fly   256 CVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVS 320
            .:.|..:.:..||||.:...::....|:||..|||.:.::..:|.:..:.||:|.:....|..:.
Human   250 SIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLV 314

  Fly   321 LSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDV 385
            ||:..::.::.                  |||                   |..........:.:
Human   315 LSLAKSIVLVK------------------FLH-------------------DEQRGGQEQPFLCL 342

  Fly   386 R-DSISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEI 449
            | |:.:|.|.....:|....   .::|:..:::.......||...|::   |:.:::..|:.::.
Human   343 RGDTDADRPRVEPRAQRAVV---TESSLYGEHLAQPGTLKEVWSQLQS---ISNYLQTQDQTDQQ 401

  Fly   450 VEDWKFVSMVLDR-------FFLWLFTLS 471
            ..:|..:....||       |.|.::|::
Human   402 EAEWLVLLSRFDRLLFQSYLFMLGIYTIT 430

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta2NP_524483.1 LIC 9..479 CDD:273305 110/479 (23%)
LGIC_ECD_nAChR_proto_alpha-like 29..247 CDD:349832 61/225 (27%)
HTR3BNP_006019.1 LIC 8..435 CDD:273305 111/484 (23%)
Neur_chan_LBD 33..239 CDD:280998 60/218 (28%)
Neur_chan_memb 246..>328 CDD:280999 21/99 (21%)
HA-stretch 381..413 5/34 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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