Protein Alignment nAChRbeta2 and CHRFAM7A

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_647536.1
• Gene: CHRFAM7A / 89832
• HGNCID: 15781
• Length: 412
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 141/423 - (33%)
• Similarity: 219/423 - (51%)
• Gaps: 61/423 - (14%)

  Fly   103 QLYVPSEHIWVP---DIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYD 164
            ||.:  :|:|:.   ||.     |..::.|..|...:..:|...:.||.|:||||.::|.:||:|
Human    13 QLLI--QHLWIAANCDIA-----DERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFD 70

  Fly   165 EQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTL 229
            .|.|.:|||||:|.|..:||:..:           .|::.:..:.|||::.:|..::|.:|....
Human    71 VQHCKLKFGSWSYGGWSLDLQMQE-----------ADISGYIPNGEWDLVGIPGKRSERFYECCK 124

  Fly   230 EPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLL 294
            ||:.|:||.:||||:||:|.:||::|||.::.|.:|||.||:|||||::|.|::|:|||||.||:
Human   125 EPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLV 189

  Fly   295 AEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMM 359
            |||:|.||.:|||:.:|...|||:|.|||..||.||..|...|....|....|.:.|::....:.
Human   190 AEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLR 254

  Fly   360 MRRTQYTLPDYDDSTP------------------------SNGYTNEIDVR--DSISDFPSEFKD 398
            |:|     |..|...|                        |||....|..|  |.:...|:  .|
Human   255 MKR-----PGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPT--PD 312

  Fly   399 SQDGAYDNGMQNSVDSDNVI-----PRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSM 458
            |  |.....|..|...|..:     |....|::.:.|..||:||...:..|:...:..:|||.:.
Human   313 S--GVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAAC 375

  Fly   459 VLDRFFLWLFTLSCVFGTLAIICQSPSLYDTRS 491
            |:||..|..|::..:..|:.|:..:|:..:..|
Human   376 VVDRLCLMAFSVFTIICTIGILMSAPNFVEAVS 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	138/409 (34%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	49/146 (34%)
CHRFAM7A	NP_647536.1	Neur_chan_LBD	<28..400	CDD:332142	133/396 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910