DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta2 and CHRNA6

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_004189.1	Gene:	CHRNA6 / 8973	HGNCID:	15963	Length:	494	Species:	Homo sapiens

Alignment Length:	519	Identity:	223/519 - (42%)
Similarity:	322/519 - (62%)	Gaps:	73/519 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWHWSLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQ 65
            :|    ||||  .|........:.|     :||:..|.|:||:.||||.|.::.:||...:.::|
Human    16 LW----LCVF--TPFFKGCVGCATE-----ERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQ 69

  Fly    66 LIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTL 130
            |..|:..||:|.||||::..|.||||||||.||.|:|.|.||::.||.||||||||..|:::|..
Human    70 LANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEG 134

  Fly   131 MTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNL 195
            .|||.|||.|.:.|.||||:||||.|::.:||:|.|.|.:|||||||:.|::||    .|.||.
Human   135 KTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDL----LIIGSK- 194

  Fly   196 VQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALT 260
                :|:.:|:.:.||:|::....|::..|....|.::|||:...:||..:|||:|||:||:.::
Human   195 ----VDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFIS 255

  Fly   261 FLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWT 325
            ||||||||||||.|||||||||:|:|||||.|::.|.||.|||.|||:|:|||||||.|:||:..
Human   256 FLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVV 320

  Fly   326 TVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMR----RTQYTLPDYDDSTP----------- 375
            ||.|||||:|:|:||.|...|:.:||..:|::::||    :|:.|   ..|:.|
Human   321 TVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGT---GSDAVPRGLARRPAKGK 382

  Fly   376 --SNG------------YTNEIDV-RDSISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPE 425
              |:|            .:||:.. :..:|..|.::.          ::||..|         ||
Human   383 LASHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWV----------VENSEHS---------PE 428

  Fly   426 VLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDT 489
            |...:.:|:|||:::|..::..|:.:|||:|:||:||.|||:|.:.|||||..:..| |.|.:|
Human   429 VEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQ-PLLGNT 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	216/499 (43%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	99/217 (46%)
CHRNA6	NP_004189.1	Neur_chan_LBD	34..484	CDD:332142	213/485 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	251	1.000	Domainoid score	I2107
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	485	1.000	Inparanoid score	I1448
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm8639
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2381
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910