Protein Alignment nAChRbeta2 and GLRA3

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_006520.2
• Gene: GLRA3 / 8001
• HGNCID: 4328
• Length: 464
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 108/501 - (21%)
• Similarity: 198/501 - (39%)
• Gaps: 101/501 - (20%)

  Fly     2 WHWSLLCVFLLVPLANSTAPISFEANPDTKRLYDDLL---SNYNRLIR-----PVVNNTETLTVW 58
            :.|....:..||....:.:..|..|........|.|:   |.|:..||     |.||  .|..::
Human    15 YFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVN--VTCNIF 77

  Fly    59 LGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPS--EHIWVPDIVLYNN 121
            :. ....:.|..:..:|   |::::|:|.|.:|.:  .||........||  :.||.||:...|.
Human    78 IN-SFGSIAETTMDYRV---NIFLRQKWNDPRLAY--SEYPDDSLDLDPSMLDSIWKPDLFFANE 136

  Fly   122 WDGNY-EVTLMTKATLKY-TGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDL 184
            ...|: |||...|....: .|.|.:........||.|:::.||.|.|.|.|:..|:.|....:..
Human   137 KGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIF 201

  Fly   185 KHLDQIPGSNLVQV--GIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLF 247
            :..|:.|    |||  |:.|.:|.|..|.|:..  .||   :|  ....|:.|..:..:.|:..:
Human   202 EWQDEAP----VQVAEGLTLPQFLLKEEKDLRY--CTK---HY--NTGKFTCIEVRFHLERQMGY 255

  Fly   248 YTVNLIVPCVALTFLTVLVFYLPSDSG-EKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKY 311
            |.:.:.:|.:.:..|:.:.|::..|:. .:|.|.|:.::::|.........:|..|
Human   256 YLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVS--------- 311

  Fly   312 LLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPK----LMMMRRTQ-------- 364
                 .:.::.:|..||:|.:         .|.|:....::|:.:    |:..||.:
Human   312 -----YVKAIDIWMAVCLLFV---------FSALLEYAAVNFVSRQHKELLRFRRKRKNKTEAFA 362

  Fly   365 ----YTLPDYDDSTPSNGYTNEIDVRDSISDFPS----EFKDSQDGAYDNGMQNSVDSDNVIPRN 421
                |...|.||           :||:|...|.:    ....::||....|..:.|   .|:|:
Human   363 LEKFYRFSDMDD-----------EVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPV---QVMPK- 412

  Fly   422 LTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWL 467
             :|:.::.:        .|..|.|.:.|......::.::...|.|:
Human   413 -SPDEMRKV--------FIDRAKKIDTISRACFPLAFLIFNIFYWV 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	107/494 (22%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	61/231 (26%)
		Cys-loop	154..168	CDD:349832	6/13 (46%)
GLRA3	NP_006520.2	LIC	12..451	CDD:273305	108/501 (22%)