DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta2 and chrna2a

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001035417.1	Gene:	chrna2a / 678575	ZFINID:	ZDB-GENE-040108-2	Length:	520	Species:	Danio rerio

Alignment Length:	512	Identity:	231/512 - (45%)
Similarity:	322/512 - (62%)	Gaps:	55/512 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VFLLVPLANSTAPIS----FEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEV 69
            :::|:.:|:...|:.    ..|:.:.| |:..|...||:..|||.|.::.:.|..||.::|||:|
Zfish    13 LWMLILIADHVQPVLSDGWIHAHAEDK-LFHKLFIGYNKWSRPVRNISDVVIVKFGLSIAQLIDV 76

  Fly    70 NLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKA 134
            :.|||:||||:|:||.|.||||||:|.|:..|..:.||||.|||||||||||.||.:.||.||||
Zfish    77 DEKNQMMTTNVWLKQEWNDYKLRWNPSEFDNVTSIRVPSEMIWVPDIVLYNNADGEFAVTHMTKA 141

  Fly   135 TLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVG 199
            .|.:||:|.|.|||||||||.::|.:||:|:|.|.||||||||:.|::|   |:||.|:
Zfish   142 HLFHTGKVSWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKID---LEQIEGT------ 197

  Fly   200 IDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTV 264
            :||.:::.|.||.|:....|.|.:.|....|.:.|||:...:||..||||:|||:||:.::.|||
Zfish   198 VDLKDYWESGEWAIINAVGTYNTKKYDCCHEIYPDITYFFIIRRLPLFYTINLIIPCLLISCLTV 262

  Fly   265 LVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCV 329
            ||||||||.|||:|||||:|:|||||.||:.||||.|||.:||:|:|||||||.|:||:..||.|
Zfish   263 LVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFV 327

  Fly   330 LNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNE------------ 382
            ||:|.||||||:|...|..:||..:|:.:.|||.:   |:......:|..|::
Zfish   328 LNVHHRSPSTHSMPRWVHSVFLDHIPRWLFMRRPE---PEKKPKKTANLSTSKSWFQQETGVDGL 389

  Fly   383 --------IDVRDSISDFPS----EFKDSQD----------GAYDNGMQNSVDSDNVIPRN---L 422
                    |.:..|||. ||    ...||:.          |...|..|:.....|::...   .
Zfish   390 VCQDMEFGIGLSTSISS-PSATSLHLSDSEPLLQKYELQHLGHVVNLCQHPAKLGNLVSEPGLLF 453

  Fly   423 TPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAI 479
            :|.||:||..||:||.|::..|:|..:.||||:|:||:||.|||:|.:.|:.||:.:
Zfish   454 SPCVLRALEGVRYIADHLRAEDEDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTIGL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	231/510 (45%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	108/217 (50%)
chrna2a	NP_001035417.1	LIC	9..513	CDD:273305	231/512 (45%)
		Neur_chan_LBD	37..243	CDD:280998	108/215 (50%)
		Neur_chan_memb	250..511	CDD:280999	114/265 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2065
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134649
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1461
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm6399
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2381
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.810