Protein Alignment nAChRbeta2 and lgc-24

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001123110.2
• Gene: lgc-24 / 6418837
• WormBaseID: WBGene00045385
• Length: 389
• Species: Caenorhabditis elegans
• Alignment Length: 359
• Identity: 74/359 - (20%)
• Similarity: 132/359 - (36%)
• Gaps: 80/359 - (22%)

  Fly    32 RLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPE 96
            :|..||..|||..:  .|...|.|.....|::..:..::..:..|:..:..:..|.|.:|:|:|.
 Worm    30 KLRSDLFKNYNGSM--PVGKGEYLEATPSLEVGFIHFIDDDHGFMSVVINAELTWIDERLKWNPA 92

  Fly    97 EYGGVEQL------YVPSEHIWVPDIVLYNNWDGNY-EVTLM----TKATLKYTGEVFWEPPAIY 150
            .|.||.::      :....:.|:| ||.|.::|..| |:.|:    .:..:.|.||:......:.
 Worm    93 NYSGVREIVEKTFEFRKDNNCWMP-IVKYRSYDRRYSELDLLEFSDARTLISYKGEIKTALQTMV 156

  Fly   151 KSSCEMNVEYFPYDEQICFM----------------------KFGSWTYNGAQVDLKHLDQIPGS 193
            .:.|:.:...:|.|.|.|.:                      ||.:..:...:|...||
 Worm   157 TTKCQFSFGEYPNDYQNCSIMLIPNQNADEFRFVSPNGYCNPKFENLEHRAVRVHDLHL------ 215

  Fly   194 NLVQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVA 258
                :|::...||............| ..||...|     :..|.|..:|......|.|.:|.:.
 Worm   216 ----MGVESNIFYTFANTYFTAEEVT-GFEYMAKT-----EFRFNLMFKRVNKLLNVKLSIPSIL 270

  Fly   259 LTFLTVLVFYLPSDSGEKVTLCISILVSLTVFF------LLLAEIIPPTSLAVPLLGKY-LLFTM 316
            ::...::....|:.        .||......||      |.:::|:|.....:|..|.. |.|.:
 Worm   271 ISMFLIIAGLFPNG--------YSIFGYAYCFFVEVMHGLYVSKILPNDIRGIPYHGALALCFLI 327

  Fly   317 ILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLF 350
            ..|.|..|.   |.:::.|:          :|||
 Worm   328 ETVFLFCWK---VFSVYARN----------QKLF 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	74/359 (21%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	51/247 (21%)
lgc-24	NP_001123110.2	LGIC_ECD	62..226	CDD:355788	34/174 (20%)
		Cys-loop	160..174	CDD:349787	4/13 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910