Protein Alignment nAChRbeta2 and htr3a

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_073791438.1
• Gene: htr3a / 571641
• ZFINID: ZDB-GENE-071012-5
• Length: 494
• Species: Danio rerio
• Alignment Length: 531
• Identity: 145/531 - (27%)
• Similarity: 260/531 - (48%)
• Gaps: 95/531 - (17%)

  Fly     4 WSLLCVFL--------LVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLG 60
            |:.||:.:        :..|.|:|...   ||....||.:.|.:.|.:.:|||.:..::.||.:.
Zfish     7 WTALCICMYGTVVDCSVKKLGNNTGRF---ANATLVRLNEFLSAGYKKGVRPVRDWRQSTTVAID 68

  Fly    61 LKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVL------- 118
            |.:..::.|:.||||:||.:|.:|:|.|..|.|||||:..|:::.:|:.:||:|||::
Zfish    69 LMVYAILNVDEKNQVLTTYVWYRQQWTDEFLMWDPEEFDEVKKISIPTANIWIPDILINEFVDVG 133

  Fly   119 --------YNNWDG---NYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKF 172
                    |...||   ||:                   |....::|.:|:..||||.|.|.:.|
Zfish   134 KSPDIPYVYVGHDGLVSNYK-------------------PIQVVTACSLNIYNFPYDVQKCSLTF 179

  Fly   173 GSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPAT------KNEEYYPDTLEP 231
            .||.:....:::. |.:.|.:    |..|.:.|....||::|.|.:|      .|::||
Zfish   180 QSWLHTTKDINIT-LMRSPEA----VKTDKSVFMNQGEWELLHVLSTYNAFSIDNDDYY------ 233

  Fly   232 FSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAE 296
             :::.|.:.:||:.|||||||::|.:.|..:.::.||||.||||:|:..|::|:..:||.:::::
Zfish   234 -AEMKFHVVIRRRPLFYTVNLLLPSMFLMVMDIVGFYLPPDSGERVSFKITLLLGYSVFLIIVSD 297

  Fly   297 IIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMR 361
            .:|.|::..||:|.|.:..|.|:.:|:..:|.::.:..:......:...|:.|.|.....|:.:|
Zfish   298 TLPATAIGTPLIGVYFVVCMALLVISLTESVLIVRLVHKQDLQSRVPQWVKHLVLEKATVLLCIR 362

  Fly   362 -------RTQYT-LPDYDDSTPSNGYTNEIDVRDSISDFPSEFKDSQDGAYDNGMQNSVDSDNVI 418
                   |:|.: ||.|.::.     .|..:.:|:::...|....:.     :..:.|.||...:
Zfish   363 NKKICSFRSQGSDLPLYKENN-----MNTAEQQDTLTMITSAIHCNH-----HSCEGSRDSGRTL 417

  Fly   419 PRNLT-----PEVLQA-LRAVRFIAQHIKDADKDNEIVEDWKFVSMVLD--RFFLWLFTL---SC 472
            ...|:     |.|:.. ||.:..|.|.::..|:..||.::|..|..|||  .|.::|.|:   ..
Zfish   418 GLGLSAHESGPPVMDGILREITTIRQFLEKKDESREIAKEWLQVGYVLDILLFRVYLLTVLAYGI 482

  Fly   473 VFGTLAIICQS 483
            ..|:|..|.|:
Zfish   483 TLGSLWSIWQN 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	140/520 (27%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	67/241 (28%)
		Cys-loop	154..168	CDD:349832	7/13 (54%)
htr3a	XP_073791438.1	None