Protein Alignment nAChRbeta2 and htr3a

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_009293684.1
• Gene: htr3a / 571641
• ZFINID: ZDB-GENE-071012-5
• Length: 482
• Species: Danio rerio
• Alignment Length: 526
• Identity: 144/526 - (27%)
• Similarity: 254/526 - (48%)
• Gaps: 97/526 - (18%)

  Fly     4 WSLLCVFL--------LVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLG 60
            |:.||:.:        :..|.|:|...   ||....||.:.|.:.|.:.:|||.:..::.||.:.
Zfish     7 WTALCICMYGTVVDCSVKKLGNNTGRF---ANATLVRLNEFLSAGYKKGVRPVRDWRQSTTVAID 68

  Fly    61 LKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVL------- 118
            |.:..::.|:.||||:||.:|.:|:|.|..|.|||||:..|:::.:|:.:||:|||::
Zfish    69 LMVYAILNVDEKNQVLTTYVWYRQQWTDEFLMWDPEEFDEVKKISIPTANIWIPDILINEFVDVG 133

  Fly   119 --------YNNWDG---NYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKF 172
                    |...||   ||:                   |....::|.:|:..||||.|.|.:.|
Zfish   134 KSPDIPYVYVGHDGLVSNYK-------------------PIQVVTACSLNIYNFPYDVQKCSLTF 179

  Fly   173 GSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPAT------KNEEYYPDTLEP 231
            .||.:....:::. |.:.|.:    |..|.:.|....||::|.|.:|      .|::||
Zfish   180 QSWLHTTKDINIT-LMRSPEA----VKTDKSVFMNQGEWELLHVLSTYNAFSIDNDDYY------ 233

  Fly   232 FSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAE 296
             :::.|.:.:||:.|||||||::|.:.|..:.::.||||.||||:|:..|::|:..:||.:::::
Zfish   234 -AEMKFHVVIRRRPLFYTVNLLLPSMFLMVMDIVGFYLPPDSGERVSFKITLLLGYSVFLIIVSD 297

  Fly   297 IIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMR 361
            .:|.|::..||:|.|.:..|.|:.:|:..:|.::.:..:......:...|:.|.|.....|:.:|
Zfish   298 TLPATAIGTPLIGVYFVVCMALLVISLTESVLIVRLVHKQDLQSRVPQWVKHLVLEKATVLLCIR 362

  Fly   362 RTQYTLPDYDDSTPSNGYTNEIDVRDSISDFPSEFKDSQDGAY---DNGMQNSVDSDNVIPRNLT 423
            ..:..      |..|.|           ||.|...:::.:.|.   .:..:.|.||...:...|:
Zfish   363 NKKIC------SFRSQG-----------SDLPLYKENNMNTAIHCNHHSCEGSRDSGRTLGLGLS 410

  Fly   424 -----PEVLQA-LRAVRFIAQHIKDADKDNEIVEDWKFVSMVLD--RFFLWLFTL---SCVFGTL 477
                 |.|:.. ||.:..|.|.::..|:..||.::|..|..|||  .|.::|.|:   ....|:|
Zfish   411 AHESGPPVMDGILREITTIRQFLEKKDESREIAKEWLQVGYVLDILLFRVYLLTVLAYGITLGSL 475

  Fly   478 AIICQS 483
            ..|.|:
Zfish   476 WSIWQN 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	139/515 (27%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	67/241 (28%)
htr3a	XP_009293684.1	LIC	21..479	CDD:273305	139/508 (27%)
		Neur_chan_LBD	40..246	CDD:280998	67/236 (28%)
		Neur_chan_memb	253..479	CDD:280999	61/242 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810