DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta2 and Htr3b

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_064670.1	Gene:	Htr3b / 57014	MGIID:	1861899	Length:	437	Species:	Mus musculus

Alignment Length:	350	Identity:	92/350 - (26%)
Similarity:	167/350 - (47%)	Gaps:	25/350 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WSLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIE 68
            ||.|.|.::..|..:|..   ..|....||...||..|::.:|||.|..|..||:|.|.:..:::
Mouse     5 WSCLLVAVVGILGTATPQ---PGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLD 66

  Fly    69 VNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTK 133
            |:::||.:.|::|.::.|.|..|.|:...:..::::.:|...:|.|||::      |..|.:...
Mouse    67 VDVQNQKLKTSVWYREVWNDEFLSWNSSLFDEIQEISLPLSALWAPDIII------NEFVDVERS 125

  Fly   134 ATLKY-----TGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGS 193
            ..|.|     :|.:....|....|:|.:....||:|.|.|.:.|.|..:....:||..|     .
Mouse   126 PDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFL-----R 185

  Fly   194 NLVQVGIDLTEFYLSVEWDILEVPATKNEEYY--PDTLEPFSDITFKLTMRRKTLFYTVNLIVPC 256
            |...:..|...|....||.:|.|.:|    |:  ..:...|:.|.|.:.:||..|.|.|:|::|.
Mouse   186 NREDIENDKRAFMNDSEWQLLSVSST----YHIRQSSAGDFAQIRFNVVIRRCPLAYVVSLLIPS 246

  Fly   257 VALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSL 321
            :.|..:.:..||||.:...::....::||..|||.:.:::.:|.::...||:|.:....|.|:.|
Mouse   247 IFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTPLIGVFFTVCMALLVL 311

  Fly   322 SVWTTVCVLNIHFRSPSTHNMSPLV 346
            |:..::.::...:....:....||:
Mouse   312 SLSKSILLIKFLYEERHSGQERPLM 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	89/344 (26%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	60/224 (27%)
Htr3b	NP_064670.1	LIC	30..431	CDD:273305	85/321 (26%)
		Neur_chan_LBD	30..233	CDD:280998	58/217 (27%)
		Neur_chan_memb	242..>313	CDD:280999	19/70 (27%)
		HA-stretch	377..409
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810