DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta2 and Htr3b

DIOPT Version :10

Sequence 1:NP_524483.1 Gene:nAChRbeta2 / 42920 FlyBaseID:FBgn0004118 Length:519 Species:Drosophila melanogaster
Sequence 2:NP_064670.1 Gene:Htr3b / 57014 MGIID:1861899 Length:437 Species:Mus musculus


Alignment Length:350 Identity:92/350 - (26%)
Similarity:167/350 - (47%) Gaps:25/350 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 WSLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIE 68
            ||.|.|.::..|..:|..   ..|....||...||..|::.:|||.|..|..||:|.|.:..:::
Mouse     5 WSCLLVAVVGILGTATPQ---PGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLD 66

  Fly    69 VNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTK 133
            |:::||.:.|::|.::.|.|..|.|:...:..::::.:|...:|.|||::      |..|.:...
Mouse    67 VDVQNQKLKTSVWYREVWNDEFLSWNSSLFDEIQEISLPLSALWAPDIII------NEFVDVERS 125

  Fly   134 ATLKY-----TGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGS 193
            ..|.|     :|.:....|....|:|.:....||:|.|.|.:.|.|..:....:||..|     .
Mouse   126 PDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFL-----R 185

  Fly   194 NLVQVGIDLTEFYLSVEWDILEVPATKNEEYY--PDTLEPFSDITFKLTMRRKTLFYTVNLIVPC 256
            |...:..|...|....||.:|.|.:|    |:  ..:...|:.|.|.:.:||..|.|.|:|::|.
Mouse   186 NREDIENDKRAFMNDSEWQLLSVSST----YHIRQSSAGDFAQIRFNVVIRRCPLAYVVSLLIPS 246

  Fly   257 VALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSL 321
            :.|..:.:..||||.:...::....::||..|||.:.:::.:|.::...||:|.:....|.|:.|
Mouse   247 IFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTPLIGVFFTVCMALLVL 311

  Fly   322 SVWTTVCVLNIHFRSPSTHNMSPLV 346
            |:..::.::...:....:....||:
Mouse   312 SLSKSILLIKFLYEERHSGQERPLM 336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta2NP_524483.1 LIC 9..479 CDD:455710 89/344 (26%)
LGIC_ECD_nAChR_proto_alpha-like 29..247 CDD:349832 60/224 (27%)
Cys-loop 154..168 CDD:349832 5/13 (38%)
Htr3bNP_064670.1 LGIC_ECD 25..233 CDD:475126 59/222 (27%)
LGIC_TM_5-HT3 236..432 CDD:349865 25/100 (25%)
TM1 helix 236..260 CDD:349865 8/23 (35%)
TM2 helix 268..289 CDD:349865 5/20 (25%)
TM3 helix 300..322 CDD:349865 4/21 (19%)
HA-stretch, determines single-channel conductance in 5-HT3 receptors. /evidence=ECO:0000250|UniProtKB:O95264 377..409
TM4 helix 407..429 CDD:349865
Blue background indicates that the domain is not in the aligned region.

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