Protein Alignment nAChRbeta2 and chrna2b

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_697298.4
• Gene: chrna2b / 568849
• ZFINID: ZDB-GENE-041001-99
• Length: 550
• Species: Danio rerio
• Alignment Length: 546
• Identity: 229/546 - (41%)
• Similarity: 317/546 - (58%)
• Gaps: 90/546 - (16%)

  Fly     5 SLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEV 69
            :|||..:...::......|...:...|:|:|    .||:..|||.|.::.:.|..||.::|||:|
Zfish    14 TLLCTIICESISCCEKTHSHAEDELFKKLFD----GYNKWSRPVPNTSDVVIVKFGLSIAQLIDV 74

  Fly    70 NLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKA 134
            :.|||:||||:|:||.|.||||||.|.:|..|..:.||||.|||||||||||.||.:.||.||||
Zfish    75 DEKNQMMTTNVWLKQEWNDYKLRWKPSDYDNVTSIRVPSELIWVPDIVLYNNADGEFAVTHMTKA 139

  Fly   135 TLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVG 199
            .|.:||:|.|.|||||||||.::|.:||:|:|.|.||||||||:.|::||:.::..
Zfish   140 HLFHTGKVRWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLERIENT--------- 195

  Fly   200 IDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTV 264
            :||.:::.|.||.|:....|.|.:.|....|.:.|||:...:||..||||:|||:||:.::.|||
Zfish   196 VDLKDYWESGEWAIINAVGTYNTKKYDCCHEIYPDITYFFIIRRLPLFYTINLIIPCLLISCLTV 260

  Fly   265 LVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCV 329
            ||||||||.|||:|||||:|:|||||.||:.||||.|||.:||:|:|||||||.|:||:..||.|
Zfish   261 LVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFV 325

  Fly   330 LNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRR-------------TQYTLPDYDDSTPSNGYTN 381
            ||:|.||||||.|...|..:||..:|:.:.|||             .|..:|.. .:.|:|.
Zfish   326 LNVHHRSPSTHKMPCWVHSVFLDLIPRWLFMRRPAPDSRRRQKLLLLQRQVPGM-TARPANA--- 386

  Fly   382 EIDVRDSISDFPSE------------FKDSQDGAYDNGMQNSVDS-------------------- 414
              .:..|.|.|..:            :||.:.|...:.:..|:.:
Zfish   387 --SLSTSTSWFRGQNSGEDESCRHFSYKDLELGTLSSAISLSLQASSPCPLGLTPPPLQKFGPAP 449

  Fly   415 ---------------------DNVIPRN-----LTPEVLQALRAVRFIAQHIKDADKDNEIVEDW 453
                                 ||:||.:     |:|.|||||..|.:||.|::..|.|..:.|||
Zfish   450 RLEVGTASRQLSGRANVTKRLDNMIPHDNPGFPLSPSVLQALEGVHYIADHLRAEDADFSVKEDW 514

  Fly   454 KFVSMVLDRFFLWLFTLSCVFGTLAI 479
            |:|:||:||.|||:|.:.|:.||:.:
Zfish   515 KYVAMVIDRIFLWMFIIVCLLGTIGL 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	226/540 (42%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	105/217 (48%)
chrna2b	XP_697298.4	LIC	6..543	CDD:273305	229/546 (42%)
		Neur_chan_LBD	35..241	CDD:280998	105/218 (48%)
		Neur_chan_memb	248..541	CDD:280999	115/299 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2065
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134649
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1461
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm6399
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2381
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910