Protein Alignment nAChRbeta2 and chrna9a

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_021326868.1
• Gene: chrna9a / 568807
• ZFINID: ZDB-GENE-090312-63
• Length: 580
• Species: Danio rerio
• Alignment Length: 596
• Identity: 174/596 - (29%)
• Similarity: 286/596 - (47%)
• Gaps: 141/596 - (23%)

  Fly     9 VFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKN 73
            :||::.::.....:........::|.:||:..|:..:|||.:..:.|.|.|.:.|||:.:::.:|
Zfish     4 IFLVIHISLLLHAVFSAQGRFAQKLLNDLMEGYSNALRPVEDTDKALNVTLQITLSQIKDMDERN 68

  Fly    74 QVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWD-----GNYEVTLMTK 133
            ||:||.|||:|.|.|..|.||.|||.|:|.:.:||..:|.||||||||.|     |..:    |.
Zfish    69 QVLTTYLWVRQIWHDAYLSWDKEEYDGLEVIRIPSNLVWRPDIVLYNNADEEDSSGPPD----TN 129

  Fly   134 ATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQV 198
            ..|:|.||:.|:.|||.||||:::|.|||:|.|.|.:.||||||||.|||            :.:
Zfish   130 VVLRYNGEITWDSPAITKSSCKVDVSYFPFDSQECNLTFGSWTYNGNQVD------------IAM 182

  Fly   199 GI---DLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALT 260
            |:   ||::|..:|||:...:||.||...|....:|:.|||:.:.::|::.||..||::||..::
Zfish   183 GMESGDLSDFVDNVEWECHGMPAVKNVIMYGCCSDPYPDITYTVLLKRRSSFYIFNLLLPCFLIS 247

  Fly   261 FLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWT 325
            ||..|.||||:||||||:|.:::|::||||.|::||.:|| |.:|||:|||.:.||.:::.|...
Zfish   248 FLAPLGFYLPADSGEKVSLGVTVLLALTVFQLMVAESMPP-SESVPLIGKYYIATMTMITASTSL 311

  Fly   326 TVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMR----------------------------- 361
            |:.::||||.......:....:.|.:.:|.|:..:.
Zfish   312 TIFIMNIHFCGAEAKPVPHWAKVLIIDYMSKIFFVYEVGENCTTPESDRGPFFSEDPLASLERDG 376

  Fly   362 ----------------RTQYTLPDYDDSTPSNGY------------------------------- 379
                            |:|:....:.|....|||
Zfish   377 YFDKGFYEDCHLDERIRSQFNGYSHRDHRHGNGYHHKNSSYRQHRHEQQRRTRSSSNSPVRQSSH 441

  Fly   380 ------------------TNEIDVRDSISDFPSEFK----DSQDG-------AYDNGMQNSVDSD 415
                              |::..::||....|.:..    |..:|       .:|||...:..:|
Zfish   442 HPKYTHFIGRDGSEKLPLTSQEKLKDSEISIPEKINGYTYDQGNGYLNGVGYLHDNGYSKTFGAD 506

  Fly   416 NVIPRNLTP--------EVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSC 472
            :.   |.|.        :..:.:|.:.:||...::.........:||.|:.|:||||:|:|.:..
Zfish   507 SY---NKTTTGTGCVCGKHQKLVRNIEYIANCFREQRGHQAKGAEWKKVAKVMDRFFMWVFFIMV 568

  Fly   473 VFGTLAIICQS 483
            ...::.::.::
Zfish   569 FLMSILVLAKA 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	174/590 (29%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	93/225 (41%)
chrna9a	XP_021326868.1	Neur_chan_LBD	25..231	CDD:308532	92/221 (42%)
		Neur_chan_memb	239..>367	CDD:308533	45/128 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910