Protein Alignment nAChRbeta2 and chrna11

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001038562.1
• Gene: chrna11 / 566141
• ZFINID: ZDB-GENE-060503-606
• Length: 589
• Species: Danio rerio
• Alignment Length: 603
• Identity: 186/603 - (30%)
• Similarity: 305/603 - (50%)
• Gaps: 130/603 - (21%)

  Fly     1 MWHWSLLCVFLLVPLANSTAPISFEA-NPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLS 64
            |||      .|...|...:|.|.... .|..:.|..:||.:|||:.|||.|:::.|||:|.:.|.
Zfish     1 MWH------SLAFTLCGISALIQVSVQGPYQRTLLKNLLKDYNRMERPVANDSQPLTVFLSMSLI 59

  Fly    65 QLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVT 129
            |:::|:.||||:|||:|:...|:|:.|:|:..||.||:.|...::.:|.|||:|||:.|..::.|
Zfish    60 QIMDVDEKNQVLTTNIWLNMHWYDHYLQWNQSEYPGVKNLRFTTDQVWTPDILLYNSADDKFDST 124

  Fly   130 LMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSN 194
            ..:...:..:|...:.||.|:.|:|.::|.:||:|.|.|.:||||||::|..:||:..:
Zfish   125 FKSNVVVNSSGYCNYLPPGIFMSTCNVDVRWFPFDIQKCELKFGSWTFDGWLLDLQMNE------ 183

  Fly   195 LVQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVAL 259
                 .|::.:..:.|||::.||.|:||.:|....||:.|:||.:|:||:||:|.:||::|||.|
Zfish   184 -----ADISGYMPNGEWDLVGVPGTRNELFYDCCKEPYPDVTFVVTIRRRTLYYALNLLIPCVLL 243

  Fly   260 TFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVW 324
            :.:|:|:|.||:|||||::|.|::|:|||||.||:|||:|.||.::||:|:|....||:|.:||.
Zfish   244 SSMTLLIFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSIPLIGQYFASIMIIVGMSVI 308

  Fly   325 TTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRR-----------------------TQYT 366
            .||.||..|...|:..||...|:.:.|.::...:.|:|                       ...:
Zfish   309 ATVVVLQYHHHDPNGGNMPKWVQLVLLQWVAWFLRMKRPGESEDPERPPCAPHLRRCSSGSQSGS 373

  Fly   367 LPDYDDSTPSN-------------------------GYTNEIDVR------------------DS 388
            ||:...|..::                         |:|:.:..:                  |.
Zfish   374 LPNAPGSASADLHHHHISSTLHPLHPQSLLQAAAAAGHTHHLHNQTNSANNNGNLLYIGFSSLDE 438

  Fly   389 ISDFPSEFKDS-QDGAYDNGMQNSVDSDNVI----PRNL-----------TPEV----------- 426
            .|. |:...|| |..:...|.:.:|.|..|:    |.:|           ||.:
Zfish   439 ASP-PALLADSVQRNSMSGGPRPTVVSPPVVGSSPPPHLPSQFCSPPPPPTPNLEATGCPSTVSG 502

  Fly   427 -----------------LQA-LRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCV 473
                             ||| |..||::|...:..|::..:.|.|||.:.|:||..|..|::..:
Zfish   503 GGGGCSCSGTSGGGDPQLQAILEEVRYVADRFRGQDENESVTEQWKFAAAVIDRLCLVAFSVFNI 567

  Fly   474 FGTLAIICQSPSLYDTRS 491
            ..|::|:..:|:..:..|
Zfish   568 ICTISILMSAPNFVEAVS 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	180/581 (31%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	83/217 (38%)
		Cys-loop	154..168	CDD:349832	6/13 (46%)
chrna11	NP_001038562.1	LIC	2..577	CDD:455710	183/592 (31%)