DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRbeta2 and chrnb2

DIOPT Version :9

Sequence 1:NP_524483.1 Gene:nAChRbeta2 / 42920 FlyBaseID:FBgn0004118 Length:519 Species:Drosophila melanogaster
Sequence 2:XP_005169811.1 Gene:chrnb2 / 561906 ZFINID:ZDB-GENE-070821-3 Length:543 Species:Danio rerio


Alignment Length:549 Identity:224/549 - (40%)
Similarity:322/549 - (58%) Gaps:96/549 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 WSLLCVFLLVPLANSTAPISFEANPDT-KRLYDDLL--SNYNRLIRPVVNNTETLTVWLGLKLSQ 65
            |:|.|:..:|......         || :||.:.||  ::||:||||..|.:|.:||.|.:.|:|
Zfish     5 WTLFCILAIVKSGYGA---------DTEERLVEHLLNPAHYNKLIRPATNGSEVVTVQLMVSLAQ 60

  Fly    66 LIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTL 130
            ||.|:.:.|:||||:|:.|.|.||:|.|.|||:.|::::.:||:|||:||:|||||.||.|||:.
Zfish    61 LISVHEREQIMTTNVWLTQEWQDYRLTWSPEEFDGMKKVRLPSKHIWLPDVVLYNNADGMYEVSF 125

  Fly   131 MTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNL 195
            .:.|.:.|.|.|||.|||||||:|::.|::||:|:|.|.:.|.||||:..:|||          :
Zfish   126 YSNAVVSYDGSVFWLPPAIYKSACKIEVKHFPFDQQNCTLSFRSWTYDRTEVDL----------V 180

  Fly   196 VQVGI-DLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVAL 259
            ::..: .:.:|..|.||||:.:|..:||.....|   :.|||:...:|||.||||:|||:|||.:
Zfish   181 LRADVASMDDFTPSGEWDIIALPGRRNENPSDPT---YVDITYDFIIRRKPLFYTINLIIPCVLI 242

  Fly   260 TFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVW 324
            |.|.:||||||||.|||:|||||:|::||||.||:::|:|||||.|||:||||:|||:||:.|:.
Zfish   243 TSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIV 307

  Fly   325 TTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYT----------------------- 366
            |:|||||:|.|||:||.|.|.|:.:||:.:|.|:.||:.:.:                       
Zfish   308 TSVCVLNVHHRSPTTHTMPPWVKLVFLNKLPALLFMRQPRNSSERQRLRQRRRANEQQEGGRGGL 372

  Fly   367 ---------LPDYDDSTPSNG-----YTNEIDVRDSISDFPSEF---------KDSQDGAYDNGM 408
                     |......:..|.     |.|    |.|:..|.:|.         .|..:|..:.|.
Zfish   373 AAGLMAGLGLSGSSSGSKENNEACTCYVN----RASVKQFGAELGGGGGGGGSTDGLNGIREGGR 433

  Fly   409 QNSVDSDN-----VIPRN-------LTPEVL--------QALRAVRFIAQHIKDADKDNEIVEDW 453
            :......|     .:||.       ||..:|        :|:..|||||.|:|..|.|..:.|||
Zfish   434 ETREGGANPLQGSALPRGKQQPPTVLTQALLAQACPGFEEAVDGVRFIANHMKSEDDDRSVSEDW 498

  Fly   454 KFVSMVLDRFFLWLFTLSCVFGTLAIICQ 482
            |:|:||:||.|||:|...|||||:.:..|
Zfish   499 KYVAMVIDRLFLWIFVFVCVFGTIGMFLQ 527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta2NP_524483.1 LIC 9..479 CDD:273305 220/539 (41%)
LGIC_ECD_nAChR_proto_alpha-like 29..247 CDD:349832 99/221 (45%)
chrnb2XP_005169811.1 LIC 4..526 CDD:273305 223/546 (41%)
Neur_chan_LBD 23..228 CDD:280998 96/217 (44%)
Neur_chan_memb 235..525 CDD:280999 115/293 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.820

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