Protein Alignment nAChRbeta2 and CHRNA9

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_060051.2
• Gene: CHRNA9 / 55584
• HGNCID: 14079
• Length: 479
• Species: Homo sapiens
• Alignment Length: 497
• Identity: 176/497 - (35%)
• Similarity: 284/497 - (57%)
• Gaps: 36/497 - (7%)

  Fly     3 HWSLLCV-FLLVPLANSTAPISFEANPD-TKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQ 65
            :||..|: |..:..|.|....:..|:.. .::|::||..:|:..:|||.:..:.|.|.|.:.|||
Human     2 NWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQ 66

  Fly    66 LIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTL 130
            :.:::.:||::|..||::|.|.|..|.||.::|.|::.:.:||:.:|.|||||||..|......:
Human    67 IKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPV 131

  Fly   131 MTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNL 195
            .|...|:|.|.:.|:.|||.||||.::|.|||:|.|.|.:.||||||||.|||:        .|.
Human   132 NTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDI--------FNA 188

  Fly   196 VQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALT 260
            :..| ||::|...|||::..:||.||...|....||:.|:||.|.::|::.||.|||::|||.::
Human   189 LDSG-DLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLIS 252

  Fly   261 FLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWT 325
            ||..|.||||:.|||||:|.::||:::|||.|::|||: |.|..|||:|||.:.||.|::.|...
Human   253 FLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIM-PASENVPLIGKYYIATMALITASTAL 316

  Fly   326 TVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDVRDSIS 390
            |:.|:||||.......:....|.:.|.:|.:::.:.       |..:|..|..::.|   ||.::
Human   317 TIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVY-------DVGESCLSPHHSRE---RDHLT 371

  Fly   391 DFPSEFKDSQ-DGAYDNGMQNSVDSDNVIPRNL-----TPEVLQA--------LRAVRFIAQHIK 441
            ...|:..:|. ..|.:..:....|.:..:..:|     .|:..::        .|.:.:||:.:|
Human   372 KVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLK 436

  Fly   442 DADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQS 483
            |....|....:||.|:.|:||||:|:|.:.....|:.||.::
Human   437 DHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARA 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	171/485 (35%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	87/218 (40%)
CHRNA9	NP_060051.2	LIC	10..474	CDD:273305	171/483 (35%)
		Neur_chan_LBD	31..236	CDD:280998	86/213 (40%)
		Neur_chan_memb	244..474	CDD:280999	76/240 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810