DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta2 and Chrna10

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001074893.1	Gene:	Chrna10 / 504186	MGIID:	3609260	Length:	447	Species:	Mus musculus

Alignment Length:	463	Identity:	159/463 - (34%)
Similarity:	246/463 - (53%)	Gaps:	59/463 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 RLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPE 96
            :|:.||.:||...:|||.:..:||.|.|.:.|||:|:::.:|||:|..||::|.|.|..|.|||:
Mouse    32 KLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLHWDPK 96

  Fly    97 EYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYF 161
            .||.::.:.:||..:|.|||||||..|.....:..|...:::.|.|.|:.|||.:|||.::|..|
Mouse    97 AYGDLDAIRIPSSLVWRPDIVLYNKADTQPPASASTNVVVRHDGAVRWDAPAITRSSCRVDVSAF 161

  Fly   162 PYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEYYP 226
            |:|.|.|.:.|||||:.|.|:|::     |..    ....|.:|..:|||.:|.:||.:....|.
Mouse   162 PFDAQRCGLTFGSWTHGGHQLDVR-----PRG----TSASLADFVENVEWRVLGMPARRRVLTYG 217

  Fly   227 DTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFF 291
            ...||:.|:||.|.:||:...|..||::|||.::.|..|.|:||:||||||:|.:::|::||||.
Mouse   218 CCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQ 282

  Fly   292 LLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPK 356
            |:|||.:||.. :|||:|||.:.||.:|:.|...|:.::|:|:..|:.|.:....|.|.|..:.|
Mouse   283 LILAESMPPAE-SVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPNAHPVPAWARVLLLGHLAK 346

  Fly   357 LMMMR---------RTQYTLPDYD-DSTPSNGYTNEIDVRDSISDFPSEFKDSQDGAYDNGMQNS 411
            .:.:|         :...:.|... .:.|..|..:|
Mouse   347 GLCVRERGEPCGQSKPLESAPSLQPPAGPPAGPCHE----------------------------- 382

  Fly   412 VDSDNVIPRNLT-PEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFG 475
                   ||.|. .|.|  |..|..||...:.........||||.::.|:|||||.:|....:..
Mouse   383 -------PRCLCHQEAL--LHHVASIAGTFRSHRAAQRRHEDWKRLARVMDRFFLGIFFCMALVM 438

  Fly   476 TLAIICQS 483
            :|.::.|:
Mouse   439 SLLVLVQA 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	158/457 (35%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	84/214 (39%)
Chrna10	NP_001074893.1	LGIC_ECD	30..236	CDD:355788	84/212 (40%)
		LGIC_TM_cation	239..>324	CDD:349853	41/85 (48%)
		TM1 helix	239..261	CDD:349853	9/21 (43%)
		Neur_chan_memb	243..437	CDD:367256	71/232 (31%)
		TM2 helix	269..290	CDD:349853	10/20 (50%)
		TM3 helix	300..322	CDD:349853	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810