Protein Alignment nAChRbeta2 and LOC4578226

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_061513968.1
• Gene: LOC4578226 / 4578226
• VectorBaseID: AGAMI1_011717
• Length: 439
• Species: Anopheles gambiae
• Alignment Length: 417
• Identity: 92/417 - (22%)
• Similarity: 167/417 - (40%)
• Gaps: 88/417 - (21%)

  Fly    31 KRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVM--------TTNLWVKQRWF 87
            |:|:   .::|::..|||.:: ||.|       :..|.:.:||..:        .:| |:...|.
Mosquito    38 KQLF---CTDYDKSQRPVEHH-ETAT-------NVSISIYMKNYALYEYDPSLHISN-WLSVSWK 90

  Fly    88 DYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMT-----KATLKYTGEVFWEPP 147
            |..|.||..:| |::.|.|....||.|.|..|:....|   |:..     |..||:||||....|
Mosquito    91 DEFLTWDRADY-GIDMLNVDESEIWRPMITSYSKKQLN---TIDRSCNDHKCELKHTGEVSCISP 151

  Fly   148 AIYKSSC-EMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEW 211
            ..|::.| ..|::: |:|...|.:.|.||....:::::      .|::.|.........|   .|
Mosquito   152 CTYEAHCTSTNIDW-PFDVMDCRLYFSSWLQYKSELNM------TGASNVSTSYVTHNHY---SW 206

  Fly   212 DILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEK 276
            .:|.  |.|....:.|. :.:..:.:.....|....||. ::.|...|..|:.||.:|...|.|:
Mosquito   207 KLLS--AEKENSNHSDD-DTYPSVVYVFKFERHMGLYTA-ILTPGFLLVVLSWLVLWLDYSSSER 267

  Fly   277 VTLCISILVSLTVFFLLL-------AEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHF 334
            :.:..:..:....|...|       .|.:|          |.|||....:.::|:|.:..:.:.:
Mosquito   268 LYILYATCIGHFTFMEFLFWHQSHQTEDVP----------KMLLFYRDSLFINVFTVILTIILKY 322

  Fly   335 RSPSTHNMSPLV-------------RKLFL--HFM--PKLMMMRRTQYTLPDYDDSTPSNGYTNE 382
            .:|..|:...|:             |.|.|  ||:  .:.::....:.....|:.:...||
Mosquito   323 TNPKPHSPERLIDRWAFRVASTSLGRVLLLRGHFIGSKRTLLREENEEGKEHYNHAGNGNG---- 383

  Fly   383 IDVRDSISDFPSEFKDSQDGAYDNGMQ 409
             |..:.:.|     :.:.:|:.|.|.:
Mosquito   384 -DTINLVID-----RTNGNGSVDAGTE 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	92/417 (22%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	56/229 (24%)
		Cys-loop	154..168	CDD:349832	4/14 (29%)
LOC4578226	XP_061513968.1	None