Protein Alignment nAChRbeta2 and chrne

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001314812.1
• Gene: chrne / 445315
• ZFINID: ZDB-GENE-040808-32
• Length: 517
• Species: Danio rerio
• Alignment Length: 516
• Identity: 167/516 - (32%)
• Similarity: 269/516 - (52%)
• Gaps: 77/516 - (14%)

  Fly     8 CVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLK 72
            ||..:..||   ..:....|.:: :|..|...||::.|||..:..|.:.|.:.|.|:.||.:|.|
Zfish    11 CVVAIALLA---TVLQVTGNEES-QLIADKFKNYSKNIRPARHADEKVKVQVKLTLTNLISLNEK 71

  Fly    73 NQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLK 137
            .:.:|||:|::.:|.||:|.|:..||..:||:.||...:|:|||||.||.||.::|.......:.
Zfish    72 EETLTTNVWIEIQWHDYRLAWNTSEYHDIEQIRVPYYTVWLPDIVLENNIDGKFDVAYYANVLIS 136

  Fly   138 YTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDL 202
            ..|.::|.|||||:|:|.:.:.|||:|.|.|.:.|.|.||:..::|:...:...|..:..|.||.
Zfish   137 SDGSMYWLPPAIYRSTCAIEITYFPFDWQNCTLVFRSQTYSANEIDIVLAEDENGKPIEWVDIDP 201

  Fly   203 TEFYLSVEWDILEVPATK--NEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVL 265
            ..|..:.||.|...||.|  |:.|.||.|| :.::.:.:.::||.|||.:|:|:||..::.|.||
Zfish   202 EAFTENGEWAIKHRPARKLTNQRYSPDDLE-YQEVYYNIIIQRKPLFYVINIILPCSLISSLVVL 265

  Fly   266 VFYLPSDS-GEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCV 329
            .::||:.: |:|:|:.||:|::.|||.:|:::.||.|||:|||:||||:|.|.:.:|.|...:.|
Zfish   266 AYFLPAKAGGQKLTVSISVLLAQTVFLILISQKIPETSLSVPLIGKYLIFVMSMTTLIVTNCIIV 330

  Fly   330 LNIHFRSPSTHNMSPLVRKLFLHFMPKL---------------------------MMMRRTQYTL 367
            ||...|||||||||..::.:||..:|:.                           :|.|..:|.|
Zfish   331 LNYSLRSPSTHNMSQSIKHIFLEVVPRYLGMAPFVDEGDQGGVYEMRERRRSSFGLMQRAEEYVL 395

  Fly   368 PD------YDDSTPSNG----YTNEIDVRDSISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNL 422
            ..      :|.....:|    ..:||||..:.:.:.|..|.:
Zfish   396 KQPRSEMMFDKQRERHGLMRTIVDEIDVSSTANLYKSLAKTA----------------------- 437

  Fly   423 TPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLW----LFTLSCVFGTLAI 479
             ||:.:.:.|..|||:..|..:.....:|.|..:..::|:...|    ||::    ||:||
Zfish   438 -PEIKECVDACNFIAESTKQQNDTGSEMESWVLIGKMIDKVCFWAAISLFSI----GTIAI 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	164/513 (32%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	80/219 (37%)
chrne	NP_001314812.1	LIC	10..495	CDD:273305	167/516 (32%)
		Neur_chan_LBD	29..245	CDD:280998	79/217 (36%)
		Neur_chan_memb	252..494	CDD:280999	78/270 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810