Protein Alignment nAChRbeta2 and pHCl-2

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Alignment Length: 511
• Identity: 117/511 - (22%)
• Similarity: 187/511 - (36%)
• Gaps: 151/511 - (29%)

  Fly    41 YNRLIRPVVNNTETLTVWLGLKLSQLIEV--NLKNQVM--TTNLWVKQRWFDYKLRWDPEEYGGV 101
            |:|::.|||:|.:...|.:.:.....|.|  ||.:..:  |....::.|:.|.:|.:..
  Fly    85 YDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSS------ 143

  Fly   102 EQLYVPSEH------------IWVPDIVLYNNWDGNY--------------EVTLMTKATLKYTG 140
               |:|:..            :|||.|.|.|......              ..|::|...|:.|
  Fly   144 ---YLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQAT- 204

  Fly   141 EVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEF 205
                    :|   |.||.:.||:|||.|.....||.||...|.|......|.|...|  :.|||:
  Fly   205 --------LY---CWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWETDNPVSFDKQ--LQLTEY 256

  Fly   206 YL--SVEWDILEVPATKNEEYYP-DTLE-PFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLV 266
            .|  |:..:.:.|   .||.|.. .:|| .:|.|:|.:.:.|:..:|.::..:|.:.:..::.:.
  Fly   257 NLIGSLYNESIRV---SNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVS 318

  Fly   267 FYLPSD-SGEKVTL-CISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLS-VWTTVC 328
            |:|.:| :..:.|| |.::|..:|                :.|..:..|..:..|::| ||..||
  Fly   319 FWLQADQTPARTTLGCTTLLSFIT----------------LSLSQENNLMKVSYVTMSEVWFLVC 367

  Fly   329 VL------------NIHFRSPSTHNMSPLVRKLFLH--FMPKLMMMRRTQYTLPDYDDSTPSNGY 379
            .:            |..:|..:...:.....|..:.  |:|.|...||..|.   ..|||.|...
  Fly   368 TIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYR---RTDSTMSTMS 429

  Fly   380 TNEID-----------------VRDSISDFPSEFK-DSQDGAYDNGMQNSVDSDNVIP----RNL 422
            |..:|                 :..|:|...|... |.||   :.....|.||....|    ..:
  Fly   430 TTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLDEQD---ETSTSESSDSSKEKPAQTFATM 491

  Fly   423 TPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLS-CVFGTL 477
            ||                             |.||:.:||...::|.|| .||..|
  Fly   492 TP-----------------------------KEVSLWIDRKMRFVFPLSFIVFNAL 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	117/511 (23%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	61/239 (26%)
		Cys-loop	154..168	CDD:349832	8/13 (62%)
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	117/511 (23%)