Protein Alignment nAChRbeta2 and nAChRalpha4

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Alignment Length: 516
• Identity: 291/516 - (56%)
• Similarity: 368/516 - (71%)
• Gaps: 48/516 - (9%)

  Fly    27 NPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKL 91
            |||.||||||||||||:|:|||||.|:.|.|.:.|||||||:||||||:|||||||:|.|:||||
  Fly     9 NPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKL 73

  Fly    92 RWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEM 156
            ||:|:|||||..|:|||:|||.||||||||.|||:||||.||||:...|.|.|:||||||||||:
  Fly    74 RWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEI 138

  Fly   157 NVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKN 221
            :|||||:|||.|.:|||||||:|.:|||:|:|:..|||:|.||:||:|||:|||||||||||.:|
  Fly   139 DVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRN 203

  Fly   222 EEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVS 286
            |::|....||:.||||.:||||||||||||:|:||:.::|||||.|||||||||||||.||||:|
  Fly   204 EKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILIS 268

  Fly   287 LTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFL 351
            |.|||||:.||||||||.||||||||:|.|||||:|:..||.|||:|||||.||.|:|.|:::|:
  Fly   269 LHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFI 333

  Fly   352 HFMPKLMMMRRTQYTL---------------PDYD----DSTPSNGYTNEI---DVRDSI----- 389
            .|:|..:.::|..|..               |.|.    |...|:||.|.:   |:..||
  Fly   334 DFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGP 398

  Fly   390 ------------------SDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRN-LTPEVLQALRAVRF 435
                              ||..:...|...|..  ||::.:.::.....: ..|::.::...|||
  Fly   399 FGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPL--GMKSPILNNPAFSHSKCLPKIHKSCFCVRF 461

  Fly   436 IAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDTRSPIDRQ 496
            ||:|.|..:...::.||||:|:|||||.|||:|||:.|.||..||.|:|:|||.|.||..|
  Fly   462 IAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLYDDRIPIIEQ 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	280/497 (56%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	154/217 (71%)
		Cys-loop	154..168	CDD:349832	10/13 (77%)
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	280/497 (56%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	154/217 (71%)
		Cys-loop	136..150	CDD:349832	10/13 (77%)