Protein Alignment nAChRbeta2 and Grd

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 444
• Identity: 85/444 - (19%)
• Similarity: 144/444 - (32%)
• Gaps: 143/444 - (32%)

  Fly     2 WHWSLLCVFLLVPLANSTAPISFEANP-----DTKR----------------------------L 33
            |.||         :...:.|.|..|:.     ||.|                            |
  Fly    57 WPWS---------IGPGSGPFSVSADSIKGRGDTHRLGEMGTSLSSSLPSSWLTQSNNHANISEL 112

  Fly    34 YDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEY 98
            .|:||..|:..|||....... |:.:.:.:..:..::..:...:.:.:.:|.|.|.:|.::
  Fly   113 LDNLLRGYDNSIRPDFGGPPA-TIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFE---- 172

  Fly    99 GGVEQLYVPS----EHIWVPDIVLYNNWDGNYEVTLMTK---ATLKYTGEVFWEPPAIYKSSCEM 156
             |.:.....|    ..||.||...||. ..:|..|:.|.   ..:...|.|.:......|:.|.|
  Fly   173 -GAQDTLALSVSMLARIWKPDTYFYNG-KQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPM 235

  Fly   157 NVEYFPYDEQICFMKFGSWTYNGAQV---------------DLK----HLDQIPGSNLVQVGID- 201
            |:..||.|.|.|.:||||:.|..:.|               |:|    .|...|..||..:...
  Fly   236 NLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKA 300

  Fly   202 ----------------------LTEFYLSVEWDILEVPATKNEEYYPD----------------- 227
                                  :|.|         ..||.||:.....
  Fly   301 AAPRPQRRPFNNKDPPRPTSKVMTTF---------AGPAAKNQHVRGTGLKLDKGAFGTGRDATG 356

  Fly   228 ------------TLE-----PFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSD-SG 274
                        |||     .:|.:.....::|....:.:.:..||..|..|:.:.|:|..: :.
  Fly   357 GSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATA 421

  Fly   275 EKVTLCISILVSLTVFFLLLAEIIPPTSLAVPL-LGKYLLFTMILVSLSVWTTV 327
            ::|:|.|:.::::|...|.....:|..|....| ...:|.|..|..::..:..|
  Fly   422 DRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVV 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	82/437 (19%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	61/328 (19%)
		Cys-loop	154..168	CDD:349832	7/13 (54%)
Grd	NP_524131.1	LIC	111..670	CDD:455710	76/381 (20%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	39/174 (22%)
		Cys-loop	233..247	CDD:349808	7/13 (54%)