Protein Alignment nAChRbeta2 and SecCl

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 485
• Identity: 101/485 - (20%)
• Similarity: 178/485 - (36%)
• Gaps: 106/485 - (21%)

  Fly    24 FEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFD 88
            ||.:.|.|||             |:|..|.....:|....|.|::..:       :..::.|:.|
  Fly    64 FEYDSDGKRL-------------PIVVKTRIYVYFLQNLNSDLLQFKM-------HALLQLRFQD 108

  Fly    89 YKLRWD----PEEYGGVEQLYVPSEHIWVPDIVLYNNWD----GNYEVTLMTKATLKYTGEVFWE 145
            .:|.:.    .:...|.:.|   ||.:|:|.|...|..:    |..|..::|  :|...|.|...
  Fly   109 KRLAYKAFNRSDNILGQKHL---SERLWLPHIFFANERESSILGTDEKDVLT--SLSPEGNVIIS 168

  Fly   146 PPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGID----LTEFY 206
            ........|.||.:.||:|:|.|.....||.||.:.:.|:.....|      :..|    |||:.
  Fly   169 TRMQASLYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEWEPHTP------ISFDPEMRLTEYN 227

  Fly   207 LSVEWDILEVPATKNEEYYPDTLE------PFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVL 265
            ::..|....:..:..     |.|.      .:|.::|.:.::|:..||.::..:|.:.:..::.:
  Fly   228 MAQFWHNTTIVQSDG-----DNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWV 287

  Fly   266 VFYLPSD-SGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCV 329
            .|:|.:| |..::.|..|.::|........::.:|..|             .|.|| .||...|.
  Fly   288 SFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVS-------------YIKVS-EVWFLGCT 338

  Fly   330 LNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDS-------TP-------SNGYT 380
            ..|         ...||...|::    .:..|:....|...:..       ||       ....:
  Fly   339 FFI---------FGSLVEFAFVN----TIWRRKENIELKKVNSKYIIKSTLTPRPARRQIGGSLS 390

  Fly   381 NEIDVR--DSISDFPS--EFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQA----LRAVRFIA 437
            ||...|  .|:.:..|  |...:.:|..:.|..|.:.....:| .:..|..:|    :.:.|...
  Fly   391 NESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLP-IIRTECAEADTVSICSARTNN 454

  Fly   438 QHIKDADKDNEIVEDWKFVSMVLDRFFLWL 467
            .||.|.|||.:.... .|.:|......:|:
  Fly   455 DHIVDVDKDKKDTPP-TFTTMTPQEIAMWI 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	101/485 (21%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	51/235 (22%)
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	101/485 (21%)
		Neur_chan_LBD	44..267	CDD:280998	53/238 (22%)
		Neur_chan_memb	275..503	CDD:280999	46/238 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447274
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030