Protein Alignment nAChRbeta2 and pHCl-1

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Alignment Length: 443
• Identity: 83/443 - (18%)
• Similarity: 155/443 - (34%)
• Gaps: 161/443 - (36%)

  Fly     6 LLCVFLLVPLANSTA---------PI------SFEANPDTKRLYDDLL--SNYNRLIRPVVN--- 50
            :||.......|.:|.         ||      .|:.:...|.:.|.||  ..|::.:.|.||
  Fly   298 MLCYLTTASTAAATQSETGALDKHPIHGIDWSKFDESSSDKEILDLLLEKKRYDKRLLPPVNDED 362

  Fly    51 --------------------NTETLTVWLGLKLSQLI---EVNLKNQVMTTNLWVKQRWFDYKLR 92
                                |..||||.:.:.|..|.   |.:||.:|   ...:.|:|.|.:|:
  Fly   363 FCCGLQSPDMATNQNARRPHNRGTLTVNVNVLLLSLASPDESSLKYEV---EFLLNQQWNDPRLQ 424

  Fly    93 W-DPEEYGGVEQLYVPSEHIWVPD--IVLYNNWDG-----NYEVTLMTKATLKYTGEVFWEPPAI 149
            : :...|..:..|: ..:.||.||  .:::.::..     ::.:.:....|:.|         |:
  Fly   425 YGNKSHYDFLNALH-HHDSIWTPDTYFIMHGDFKDPIIPMHFALRIFRNGTITY---------AM 479

  Fly   150 YKS---SCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEW 211
            .:.   ||:.::..||:|:..|.....|.:|..||:  |::                       |
  Fly   480 RRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQI--KYV-----------------------W 519

  Fly   212 DILEVPATKNEEYYPDTLEP---------------------------FSDITFKLTMRRKTLFYT 249
                    ||:|   |||..                           :|.:..:||..|...:|.
  Fly   520 --------KNDE---DTLRKSPSLTTLNAYLIKNQTTACDQNSWRGNYSCLQVELTFTRDRAYYF 573

  Fly   250 VNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLF 314
            ..:.:|.:.|...:.:.|:|..::   |...:.|.|:..:.|...:.....|   :|::..
  Fly   574 TTVFIPGIILVTSSFITFWLEWNA---VPARVMIGVTTMLNFFTTSNGFRST---LPVVSN---- 628

  Fly   315 TMILVSLSVWTTVCV------------LNIHFRSPSTHNM------SPLVRKL 349
               |.:::||..||:            :|...|....||:      :|:.::|
  Fly   629 ---LTAMNVWDGVCMCFIYASLLEFVCVNYVGRKRPLHNVVYRPGENPVTQRL 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	81/440 (18%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	54/283 (19%)
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	53/276 (19%)
		Neur_chan_memb	578..>682	CDD:280999	21/114 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100