Protein Alignment nAChRbeta2 and chrna1.2

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_012825723.1
• Gene: chrna1.2 / 394991
• XenbaseID: XB-GENE-5932067
• Length: 457
• Species: Xenopus tropicalis
• Alignment Length: 482
• Identity: 201/482 - (41%)
• Similarity: 294/482 - (60%)
• Gaps: 49/482 - (10%)

  Fly     5 SLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEV 69
            |.|..|.:     :..|: |.::.:| ||..||.:|||:::|||....:.:.|.:||:|.|||.|
 Frog     6 SCLIFFFI-----AAGPV-FSSDHET-RLIGDLFANYNKVVRPVETYKDQVVVTVGLQLIQLINV 63

  Fly    70 NLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKA 134
            :..||:::||:.:||:|.|..|:|||.:||||::|.:||..:|.||:|||||.||::.::..||.
 Frog    64 DEVNQIVSTNIRLKQQWVDVNLKWDPAKYGGVKKLRIPSSEVWCPDLVLYNNADGDFAISKDTKI 128

  Fly   135 TLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVG 199
            .|::||::.|.||||:||.||:.|.:||:|:|.|.||||:|||:|..|.:......|
 Frog   129 LLEHTGKITWTPPAIFKSYCEIIVTHFPFDQQNCSMKFGTWTYDGTLVVINPDRDRP-------- 185

  Fly   200 IDLTEFYLSVEWDILEVPATKNEEYY---PDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTF 261
             ||:.|..|.||.:.:....|:..||   ||  :|:.|||:...::|..|::.||:|:||:..:|
 Frog   186 -DLSNFMASGEWMMKDYRCWKHWVYYTCCPD--KPYLDITYHFVLQRLPLYFIVNVIIPCLLFSF 247

  Fly   262 LTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTT 326
            ||.||||||:|||||:||.||:|:|||||.|::.|:||.||.||||:|||:||||:.|..|:..|
 Frog   248 LTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIIT 312

  Fly   327 VCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLM----MMRRTQYTLPDYDDSTPSNGYTNEIDVRD 387
            |.|:|.|.||||||.|.|.|||:|:..:|.:|    |.|.:|       :..|...:..|:|:.|
 Frog   313 VIVINTHHRSPSTHTMPPWVRKIFIDTIPNIMFFSTMKRPSQ-------EKQPQTTFAEEMDISD 370

  Fly   388 SISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVED 452
            ............|..|..|                 |:|..|:..:::||:.:|...:.|:..|:
 Frog   371 ISGKLGPAAVTYQSPALKN-----------------PDVKSAIEGIKYIAETMKSDQESNKASEE 418

  Fly   453 WKFVSMVLDRFFLWLFTLSCVFGTLAI 479
            ||||:||||...|.:|...||.||||:
 Frog   419 WKFVAMVLDHILLAVFMTVCVIGTLAV 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	198/476 (42%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	94/220 (43%)
		Cys-loop	154..168	CDD:349832	7/13 (54%)
chrna1.2	XP_012825723.1	LIC	8..447	CDD:455710	200/480 (42%)
		LGIC_ECD_nAChR_A1	22..231	CDD:349815	94/220 (43%)
		Cys-loop	148..162	CDD:349815	7/13 (54%)