Protein Alignment nAChRbeta2 and chrna7a

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_957513.1
• Gene: chrna7a / 394199
• ZFINID: ZDB-GENE-040108-3
• Length: 509
• Species: Danio rerio
• Alignment Length: 499
• Identity: 182/499 - (36%)
• Similarity: 285/499 - (57%)
• Gaps: 59/499 - (11%)

  Fly    31 KRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDP 95
            :|||.||:.:||.|.|||.|:|.:|||:..:.|.|:::|:.||||:|||:|::..|:||.|:|:.
Zfish    27 RRLYRDLMKDYNPLERPVFNDTHSLTVYFSMSLMQIMDVDEKNQVLTTNIWLQLYWYDYYLQWNA 91

  Fly    96 EEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEY 160
            .||.||..:..|...||.|||:|||:.|..::.|..|...:..:|...:.||.|:||:|.::|.:
Zfish    92 SEYPGVTNVRFPDSQIWKPDILLYNSADERFDATFHTNVLVNSSGACQYLPPGIFKSTCYIDVRW 156

  Fly   161 FPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEYY 225
            ||:|.|.|.:|||||||.|..:||:.:|           .|:|.:..:.|||::|||..:||.:|
Zfish   157 FPFDLQRCDLKFGSWTYGGWSLDLQMID-----------ADITGYIANGEWDLVEVPGRRNERFY 210

  Fly   226 PDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVF 290
            ....||:.|:||.:.|||:||:|.:||::|||.::.|.:|||.||:|||||::|.|::|:|||||
Zfish   211 DCCKEPYPDVTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVF 275

  Fly   291 FLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMP 355
            .||:|||:|.||.:|||:.:|...||::|.|||..||.||..|:..|....|....|.:.|::..
Zfish   276 MLLVAEIMPATSDSVPLIAQYFATTMVIVGLSVIATVWVLQYHYHDPEGGKMPKWTRVVLLNWCA 340

  Fly   356 KLMMMRRTQYTLPDYDDSTP-------------------------SNGYTNEIDVR--DSISDFP 393
            ..:.|:|     |..|...|                         :||....|..|  |:|
Zfish   341 WFLRMKR-----PGEDKVRPACHNKQPRSSLSSVDLNISPGVAQSTNGNLLYIGFRGMDTI---- 396

  Fly   394 SEFKDSQD-GAYDNGMQNSVDSDNVIP-------RNLTP---EVLQALRAVRFIAQHIKDADKDN 447
             .:..|.| |...:.:..:.:.|.::|       .:..|   |:.:.|..||:|::..:|.|:::
Zfish   397 -HYATSPDSGVICSRLVATGEEDVLLPGAQASSVSSSGPGETELSKILDEVRYISKRFRDQDEED 460

  Fly   448 EIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDTRS 491
            .:..:|||.:.|:||..|..|:|..:..|:.|:..:|:..:..|
Zfish   461 TVCNEWKFAASVIDRLCLMAFSLFTILCTIGILMSAPNFVEAIS 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	179/485 (37%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	92/215 (43%)
		Cys-loop	154..168	CDD:349832	6/13 (46%)
chrna7a	NP_957513.1	LIC	3..496	CDD:455710	180/489 (37%)