Protein Alignment nAChRbeta2 and lgc-28

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001022053.1
• Gene: lgc-28 / 3565225
• WormBaseID: WBGene00044301
• Length: 397
• Species: Caenorhabditis elegans
• Alignment Length: 405
• Identity: 78/405 - (19%)
• Similarity: 152/405 - (37%)
• Gaps: 79/405 - (19%)

  Fly     5 SLLCVFLL-VPLANSTAPISFEANPDTK------RLYDDLL----SNYNRLIRPVVNNTETLTVW 58
            :||.:|.| :.|..|...:......:||      :.:||.:    ..|.:|| |:
 Worm     8 ALLSMFSLNIQLEPSPGEMEKRYEAETKLREDITKRFDDTMPIKKDGYLQLI-PL---------- 61

  Fly    59 LGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIW----------- 112
              |.:..:.::..:..|:...|.....|.|.:|.|:|..|.|:.........:|
 Worm    62 --LHVDHIHDIQDEQGVLKMALTFTFTWMDERLMWNPSNYSGIRTFSTTRHEMWRKKFWTPTLMM 124

  Fly   113 --VP------------DIVLYNNWDGNYEVTLMTKATLK-YTGEVFWEPPAIYKSSCEMNVEYFP 162
              ||            |:.:|.:..|....:.....|:. .||  |...|..|| :|...:....
 Worm   125 TDVPNSRRPSDVFKPFDMDIYISSSGMVRTSARMMLTIPCRTG--FGSYPNDYK-NCTFTLMSPY 186

  Fly   163 YDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEYYPD 227
            |.:|..|.::|...:....:..:..|.:   :...:.||...:|:.:..::::    ...::.|.
 Worm   187 YADQFRFAQWGGAEFTRYLMSSRVTDVL---DFQLINIDTRNYYMFLGSEVVD----DFSKFKPR 244

  Fly   228 TLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCI-SILVSLTVFF 291
            ....|  ..:.|.::|...|.:|.||.|...:.....:..:||...|   .:|. |.||..|:|.
 Worm   245 HCRSF--YRYNLVLKRVNKFVSVQLIAPISVIAVFLAISGFLPHFYG---LVCAGSALVYETIFT 304

  Fly   292 LLLAEIIPPTSLAVPLLGKYLLF----TMILVSLSVW-------TTVCVLNIHFRSPSTHNMSPL 345
            ..:.:::|.....:|::...|.|    |::|::..|:       |.......:|....|.....|
 Worm   305 YDVEQVLPKDYSGMPMIAILLCFLFAETIVLLAWKVFSINTRSHTVFTAFPEYFDDEITSKKEKL 369

  Fly   346 VRKLFLHFMPKLMMM 360
            ::  |:.::.|.:|:
 Worm   370 LK--FVIWVDKFLMV 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	76/401 (19%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	44/253 (17%)
lgc-28	NP_001022053.1	LGIC_ECD	62..>187	CDD:355788	24/127 (19%)
		LIC	67..>329	CDD:273305	53/276 (19%)
		Cys-loop	164..178	CDD:349787	6/16 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810