Protein Alignment nAChRbeta2 and lgc-8

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001023533.2
• Gene: lgc-8 / 3564870
• WormBaseID: WBGene00013338
• Length: 438
• Species: Caenorhabditis elegans
• Alignment Length: 464
• Identity: 121/464 - (26%)
• Similarity: 211/464 - (45%)
• Gaps: 64/464 - (13%)

  Fly    30 TKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNL---WVKQRWFDYKL 91
            :::|.|.|:..|:..||||:|..:||  ::.:.::.:..:.|.....|.|.   ::.| |.|..|
 Worm    28 SEQLKDVLMEGYDSSIRPVINERDTL--FINISINSMSFLTLDPAEETINFSGEFILQ-WKDEFL 89

  Fly    92 RWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEV-TLMTKATLKYTGEVFWEPPAIYKSSCE 155
            .|:..:| .:..|.:....:|.||..:..:.|.||.: |.....::||.|.|.....|::.:.|:
 Worm    90 FWNKSDY-NITWLKLKESFLWTPDTTVSTSIDTNYLIETSERYVSVKYDGTVRQNIYAVFTNLCD 153

  Fly   156 MNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATK 220
            ||:..||||:|.|.:|.|.|:|.     :|.:..|.|.: ::......:|..:.|||...:.::.
 Worm   154 MNINEFPYDQQTCMIKMGPWSYT-----MKEVTCIVGGD-IERNETTGKFQGNSEWDFEGIVSSV 212

  Fly   221 NEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDS----GEKVTLCI 281
            .|...||....||::.|.||::|:..||...|::|...:|.:.:...:.|:.:    .|:|.|.|
 Worm   213 GETEDPDVNFTFSEVHFALTVKRRPQFYVWVLLIPTYIITVVCIFGLFTPTANHGLREERVNLGI 277

  Fly   282 SILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLV 346
            :.|:|..|...::|..:|.|| .:||||.::|..:.:|::.|...|.||.:|.|: .|....|..
 Worm   278 TTLLSSAVILQIVANAMPKTS-ELPLLGNFILAEIFVVAIGVLFAVLVLTLHQRA-HTREWRPPA 340

  Fly   347 RKLFLHFMPKLMMMRRTQYTLPDYDDSTPSN-GYTNEIDVRDSISDFPSEFKDSQDGAYDNGMQN 410
            ..|::..|...........|...:..||... .||.|                   |||
 Worm   341 WMLWILRMTGSSKFLSRNITKIRHKSSTAERIHYTGE-------------------GAY------ 380

  Fly   411 SVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMV--LDRFFLWLFTLSCV 473
                   :.:|| .|.||::|      ::|::.|:|  ...:..:|...  ||...|.:|.:...
 Worm   381 -------LFKNL-DESLQSVR------EYIQEEDRD--YFRELTYVKFFDRLDFLLLLIFQVGNA 429

  Fly   474 FGTLAIICQ 482
            ..||.::.|
 Worm   430 LVTLFLVKQ 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	120/459 (26%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	62/220 (28%)
		Cys-loop	154..168	CDD:349832	8/13 (62%)
lgc-8	NP_001023533.2	Neur_chan_LBD	29..237	CDD:460752	62/217 (29%)
		LGIC_TM_cation	239..>328	CDD:349853	27/89 (30%)
		TM1 helix	239..262	CDD:349853	5/22 (23%)
		TM2 helix	274..295	CDD:349853	6/20 (30%)
		TM3 helix	305..327	CDD:349853	6/21 (29%)