Protein Alignment nAChRbeta2 and nAChRalpha5

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Alignment Length: 522
• Identity: 189/522 - (36%)
• Similarity: 300/522 - (57%)
• Gaps: 54/522 - (10%)

  Fly     9 VFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKN 73
            :|||:.| |.:|.:.. |....|||..|||..||.|.|||:|.::.|.:..||.|.|:|:|:.||
  Fly   294 IFLLIYL-NLSAKVCL-AGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKN 356

  Fly    74 QVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKY 138
            |::.||:|:|..|.|..|||:..:||||:.|.:|...||.||:::||:.|..::.|..|...::.
  Fly   357 QLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRN 421

  Fly   139 TGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLT 203
            .|...:.||.|:||:|::::.:||:|:|.|.||||||||:|.|:||:..|:..|        |::
  Fly   422 NGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGG--------DIS 478

  Fly   204 EFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFY 268
            .:.|:.||::|.||..:||.||....||:.||||.:.:||:||:|..|||:|||.:..:.:|.|.
  Fly   479 SYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFT 543

  Fly   269 LPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIH 333
            ||.|||||::|.::||:|||||..::||.:|.||.||||||.|....|.:|:.||.:|:.:||.|
  Fly   544 LPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYH 608

  Fly   334 FRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNE--------IDVRD--- 387
            .|:..||.||..:|.:||.::|.::.|.|....|.....:||.:..::|        :::::
  Fly   609 HRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSS 673

  Fly   388 -----SISDFPSEFK------------------------DSQDGAY----DNGMQNSVDSDNVIP 419
                 ::.|...:|:                        ...||:.    ...|.::|.....|.
  Fly   674 KSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIK 738

  Fly   420 RNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSP 484
            .:...|:...|:.:|||...::..|:.|:|..||||.:||:||..|.:||:..:..|:|::..:|
  Fly   739 SSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAP 803

  Fly   485 SL 486
            .:
  Fly   804 HI 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	187/513 (36%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	93/217 (43%)
		Cys-loop	154..168	CDD:349832	5/13 (38%)
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	181/496 (36%)