DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta2 and HTR3A

DIOPT Version :9

Sequence 1:NP_524483.1 Gene:nAChRbeta2 / 42920 FlyBaseID:FBgn0004118 Length:519 Species:Drosophila melanogaster
Sequence 2:NP_998786.3 Gene:HTR3A / 3359 HGNCID:5297 Length:510 Species:Homo sapiens


Alignment Length:524 Identity:132/524 - (25%)
Similarity:253/524 - (48%) Gaps:69/524 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MW-HWSLLCVFLLVPLANSTAPISFE-ANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKL 63
            :| ..:||.:.|...||...|..|.. ..|...||.|.||:||.:.:|||.:..:..||.:.:.:
Human     3 LWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIV 67

  Fly    64 SQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEV 128
            ..::.|:.||||:||.:|.:|.|.|..|:|:||::..:.:|.:|::.||||||::      |..|
Human    68 YAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILI------NEFV 126

  Fly   129 TLMTKATLKYT-----GEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLD 188
            .:.....:.|.     |||....|....::|.:::..||:|.|.|.:.|.||.:....:::. |.
Human   127 DVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINIS-LW 190

  Fly   189 QIPGSNLVQVGIDLTEFYLSVEWDILEV-PATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNL 252
            ::|    .:|..|.:.|....||::|.| |..:  |:..::...::::.|.:.:||:.|||.|:|
Human   191 RLP----EKVKSDRSVFMNQGEWELLGVLPYFR--EFSMESSNYYAEMKFYVVIRRRPLFYVVSL 249

  Fly   253 IVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGK------- 310
            ::|.:.|..:.::.||||.:|||:|:..|::|:..:||.:::::.:|.|::..||:||       
Human   250 LLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRA 314

  Fly   311 -------------------------YLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLF 350
                                     |.:..|.|:.:|:..|:.::.:..:......:...:|.|.
Human   315 QSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLV 379

  Fly   351 LHFMPKLMMMRRTQYTLPDYDDST----PSNGYTNEIDVRDSISDFPSEFKDSQDGAYDNGMQNS 411
            |..:..|:.:|         :.||    |:.....:.|...::.:..|.....||  ::...::.
Human   380 LERIAWLLCLR---------EQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQD--FEKSPRDR 433

  Fly   412 VDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGT 476
            . |....||..:..|...|:.:..|.|.::..|:..|:..||..|..|||:....::.|:.:..:
Human   434 C-SPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYS 497

  Fly   477 LAII 480
            :.::
Human   498 ITLV 501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta2NP_524483.1 LIC 9..479 CDD:273305 129/512 (25%)
LGIC_ECD_nAChR_proto_alpha-like 29..247 CDD:349832 65/223 (29%)
HTR3ANP_998786.3 LIC 23..504 CDD:273305 126/504 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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