Protein Alignment nAChRbeta2 and nAChRalpha7

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 526
• Identity: 192/526 - (36%)
• Similarity: 296/526 - (56%)
• Gaps: 64/526 - (12%)

  Fly     7 LCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNL 71
            |.:.:::|        :..|.|..|||...||.|||.|.|||||.::.|.:..||.|.|:|:|:.
  Fly    46 LGLLIMIP--------ACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDE 102

  Fly    72 KNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATL 136
            |||::.||:|:|..|.|..|||:..|:|||..|.:|...:|.||:::||:.|..::.|..|...:
  Fly   103 KNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVV 167

  Fly   137 KYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGID 201
            :..|...:.||.|:||:|::::.:||:|:|.|.||||||||:|.|:||:..|:..|        |
  Fly   168 RNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGG--------D 224

  Fly   202 LTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLV 266
            ::.|..:.|||:|.||..:||.||....||:.||||.:.:|||||:|..|||||||.:..:.:|.
  Fly   225 ISSFITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLG 289

  Fly   267 FYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLN 331
            |.||.|||||::|.::||:|||||..::||.:|.||.||||||.|....|.:|:.||.:|:.:||
  Fly   290 FTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILN 354

  Fly   332 IHFRSPSTHNMSPLVRKLFLHFMPKLMMMRR---TQYTLPDYDDSTPSNG--------------- 378
            .|.|:|.||.||..:|.:||:::|.::.|:|   ..|..|....|:.|:.
  Fly   355 YHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKE 419

  Fly   379 ------YTNEIDVRDSI--------SDFPSE-------FKDSQDGAYD---------NGMQNSVD 413
                  ..|.:|:.|..        :..|.:       ::...||:..         :|..:...
  Fly   420 RSSKSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAI 484

  Fly   414 SDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLA 478
            |...:..:...|:...|:.:|:|.:.:|..|:.::|..||||.:||:||..|.:|||..:..|||
  Fly   485 SHTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLA 549

  Fly   479 IICQSP 484
            ::..:|
  Fly   550 VLFSAP 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	189/517 (37%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	95/217 (44%)
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	185/496 (37%)
		Neur_chan_LBD	61..268	CDD:280998	93/214 (43%)
		Neur_chan_memb	275..552	CDD:280999	89/276 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447306
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940