Protein Alignment nAChRbeta2 and nAChRalpha3

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001285015.1
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Alignment Length: 810
• Identity: 314/810 - (38%)
• Similarity: 398/810 - (49%)
• Gaps: 310/810 - (38%)

  Fly     2 WHWSLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQL 66
            |....:.:.|::...:|:.     ||||.||||||||||||:|:|||||.|:.|||.:.||||||
  Fly     3 WFQVTIDMILVLSFISSST-----ANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQL 62

  Fly    67 IEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLM 131
            |:||||||:|||||||:|.|:||||:|:|:||||||.|:|||:|||.||||||||.|||:||||.
  Fly    63 IDVNLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLA 127

  Fly   132 TKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLV 196
            |||||.|||.|.|.||||||||||::|||||:|||.|.||||||||:|.||||:|:|::.|:|:|
  Fly   128 TKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVV 192

  Fly   197 QVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTF 261
            :||:||:|||.|||||||||||.:||::|....||:.||||.:||||||||||||||:||:.::|
  Fly   193 EVGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISF 257

  Fly   262 LTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTT 326
            ||:|||||||||||||:|.||||:||||||||||||||||||.||||||::||||||.:.|:..|
  Fly   258 LTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVT 322

  Fly   327 VCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDST------PSNGYTNEIDV 385
            |.|||||||||.||.|:|.||.:|::.:|:.::|||..|.:.:...|:      ..||    :::
  Fly   323 VLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNG----LEL 383

  Fly   386 RDSISDFP--------------------------------------------------------- 393
            ||.|...|
  Fly   384 RDQIPPLPPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPP 448

  Fly   394 ------------SEFKDSQ------------------------------------------DGAY 404
                        |...|:|                                          :|.|
  Fly   449 TMSTANQQTSTTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGY 513

  Fly   405 ---------------------------------------DNGMQNSVDSDNVIPRNLT------- 423
                                                   |.||.|    .|||....|
  Fly   514 GGHGQSGGHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMAN----PNVIKSTTTVNSVATA 574

  Fly   424 ----------------------------------------------------------------- 423
                                                                             
  Fly   575 STLADSCCSGTIQIHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAA 639

  Fly   424 ----------------------------------------------------------------- 423
                                                                             
  Fly   640 AAAAAAGGPSTSAAAAAAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTC 704

  Fly   424 PEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYD 488
            ||:.:|:..|.:||...:..::...:.||||:|:|||||.|||:||::.|.||..||.|:|:|||
  Fly   705 PELHKAMDGVTYIADQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAPTLYD 769

  Fly   489 TRSPIDRQLSEIPLRKNNFMLPPDIVRQVL 518
            ||.|||.:||||.    :....|::.|.||
  Fly   770 TRMPIDIKLSEIA----STTAKPNVARPVL 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	293/762 (38%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	159/217 (73%)
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	156/214 (73%)
		Neur_chan_memb	248..>359	CDD:280999	77/110 (70%)
		Neur_chan_memb	<683..760	CDD:280999	24/76 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447328
Domainoid	1	1.000	250	1.000	Domainoid score	I2065
eggNOG	1	0.900	-	-		E1_KOG3645
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1461
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm6399
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X294
	11	10.800