Protein Alignment nAChRbeta2 and HTR3E

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001243543.1
• Gene: HTR3E / 285242
• HGNCID: 24005
• Length: 482
• Species: Homo sapiens
• Alignment Length: 490
• Identity: 118/490 - (24%)
• Similarity: 197/490 - (40%)
• Gaps: 104/490 - (21%)

  Fly    37 LLSNYNRL-IRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGG 100
            |.|.:||. .|||.|.:....|.:...:|.:::|               .|.:..:.|:|||..|
Human    60 LNSVFNRKPFRPVTNISVPTQVNISFAMSAILDV---------------VWDNPFISWNPEECEG 109

  Fly   101 VEQLYVPSEHIWVPDIVLYN---NWDGNYEV--------------TLM-----TKATLKYT---G 140
            :.::.:.::::|:|||.:..   :..|..||              .||     .|....|.   |
Human   110 ITKMSMAAKNLWLPDIFIIELCVSRAGQREVPSPGSHRDHSLPLGPLMDVDKTPKGLTAYVSNEG 174

  Fly   141 EVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLD------QIPGS--NLVQ 197
            .:.::.|....|.|.:::.|||:|:|.|.:.|.|:.|.   ||...||      :|..:  |::|
Human   175 RIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYT---VDSMLLDMEKEVWEITDASRNILQ 236

  Fly   198 VGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFL 262
            .         ..||::|.:.....:......|  :..|.|.:.:||:...|.:||:||...|..:
Human   237 T---------HGEWELLGLSKATAKLSRGGNL--YDQIVFYVAIRRRPSLYVINLLVPSGFLVAI 290

  Fly   263 TVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTV 327
            ..|.||||..||.:|...|::|:...||.|::::::|.:  ..||:|.|....:.|:..|:..|:
Human   291 DALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTS--GTPLIGVYFALCLSLMVGSLLETI 353

  Fly   328 CVLNIHFRSPSTHNMSPLVR---KLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDVRDSI 389
            .:  .|....:|....||.|   .|.||    .....|...|.|..::..|  |.|
Human   354 FI--THLLHVATTQPPPLPRWLHSLLLH----CNSPGRCCPTAPQKENKGP--GLT--------- 401

  Fly   390 SDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWK 454
               |:...         |::....|...:|.....|:.......|  ||...:|.|.:. ||.|.
Human   402 ---PTHLP---------GVKEPEVSAGQMPGPAEAELTGGSEWTR--AQREHEAQKQHS-VELWL 451

  Fly   455 FVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDT 489
            ..|..:|.....|:.|......:.:||    |::|
Human   452 QFSHAMDAMLFRLYLLFMASSIITVIC----LWNT 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	114/478 (24%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	56/243 (23%)
HTR3E	NP_001243543.1	Neur_chan_LBD	70..273	CDD:280998	52/231 (23%)
		Neur_chan_memb	280..>379	CDD:280999	31/102 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810