Protein Alignment nAChRbeta2 and GLRA2

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_002054.1
• Gene: GLRA2 / 2742
• HGNCID: 4327
• Length: 452
• Species: Homo sapiens
• Alignment Length: 352
• Identity: 80/352 - (22%)
• Similarity: 149/352 - (42%)
• Gaps: 58/352 - (16%)

  Fly    39 SNYNRLIR-----PVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEY 98
            |.|:..||     |.||  .|..:::. ....:.|..:..:|   |::::|:|.|.:|.:  .||
Human    56 SGYDARIRPNFKGPPVN--VTCNIFIN-SFGSVTETTMDYRV---NIFLRQQWNDSRLAY--SEY 112

  Fly    99 GGVEQLYVPS--EHIWVPDIVLYNNWDGNY-EVTLMTK-ATLKYTGEVFWEPPAIYKSSCEMNVE 159
            ........||  :.||.||:...|....|: :||...| ..:...|:|.:........||.|:::
Human   113 PDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLK 177

  Fly   160 YFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQV--GIDLTEFYLSVEWDILEVPATKNE 222
            .||.|.|.|.|:..|:.|....:..:.|...|    |||  |:.|.:|.|..|.::  ...||
Human   178 NFPMDVQTCTMQLESFGYTMNDLIFEWLSDGP----VQVAEGLTLPQFILKEEKEL--GYCTK-- 234

  Fly   223 EYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSG-EKVTLCISILVS 286
             :|  ....|:.|..|..:.|:..:|.:.:.:|.:.:..|:.:.|::..|:. .:|.|.|:.:::
Human   235 -HY--NTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLT 296

  Fly   287 LTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFL 351
            :|.........:|..|              .:.::.:|..||:|.:         .:.|:....:
Human   297 MTTQSSGSRASLPKVS--------------YVKAIDIWMAVCLLFV---------FAALLEYAAV 338

  Fly   352 HFMPK----LMMMRRTQYTLPDYDDST 374
            :|:.:    .:.:||.|......:|.|
Human   339 NFVSRQHKEFLRLRRRQKRQNKEEDVT 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	80/352 (23%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	58/218 (27%)
		Cys-loop	154..168	CDD:349832	6/13 (46%)
GLRA2	NP_002054.1	LIC	46..441	CDD:273305	80/352 (23%)