Protein Alignment nAChRbeta2 and Chrna7

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_063137740.1
• Gene: Chrna7 / 25302
• RGDID: 2348
• Length: 531
• Species: Rattus norvegicus
• Alignment Length: 531
• Identity: 178/531 - (33%)
• Similarity: 277/531 - (52%)
• Gaps: 100/531 - (18%)

  Fly    31 KRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDP 95
            :|||.:|:.|||.|.|||.|:::.|||:..|.|.|:::|:.||||:|||:|::..|.|:.|:|:.
  Rat    27 RRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNM 91

  Fly    96 EEYGGVEQLYVPSEHIWVPDIVLYNNW-----------------------------DGNYEVTLM 131
            .||.||:.:..|...||.|||:|||:.                             |..::.|..
  Rat    92 SEYPGVKNVRFPDGQIWKPDILLYNSGCQLHFDQDLQNMLLREACAQAGEDLRVSADERFDATFH 156

  Fly   132 TKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLV 196
            |...:..:|...:.||.|:||||.::|.:||:|.|.|.:|||||:|.|..:||:..:
  Rat   157 TNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQE-------- 213

  Fly   197 QVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTF 261
               .|::.:..:.|||::.:|..:||::|....||:.|:|:.:||||:||:|.:||::|||.::.
  Rat   214 ---ADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISA 275

  Fly   262 LTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTT 326
            |.:|||.||:|||||::|.|::|:|||||.||:|||:|.||.:|||:.:|...|||:|.|||..|
  Rat   276 LALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVT 340

  Fly   327 VCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTP---------------- 375
            |.||..|...|....|....|.:.|::....:.|:|     |..|...|
  Rat   341 VIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKR-----PGEDKVRPACQHKPRRCSLASVEL 400

  Fly   376 --------SNGYTNEIDVR-----------DS------ISDFPSEFKDSQDGAYDNGMQNSVDSD 415
                    |||....|..|           ||      ::..|:..:....||:.:      |.|
  Rat   401 SAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPS------DGD 459

  Fly   416 NVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAII 480
                    |::.:.|..||:||...:..|:...|..:|||.:.|:||..|..|::..:..|:.|:
  Rat   460 --------PDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGIL 516

  Fly   481 CQSPSLYDTRS 491
            ..:|:..:..|
  Rat   517 MSAPNFVEAVS 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	175/517 (34%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	87/244 (36%)
		Cys-loop	154..168	CDD:349832	6/13 (46%)
Chrna7	XP_063137740.1	None