DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta2 and Chrna5

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_058774.2	Gene:	Chrna5 / 25102	RGDID:	2347	Length:	467	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	197/462 - (42%)
Similarity:	291/462 - (62%)	Gaps:	67/462 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEE 97
            |:.||..:|.|.:|||.:.::.:.:..||.:|||::|:.|||:||||:|:||.|.|.||||:|::
  Rat    50 LFRDLFEDYERWVRPVEHLSDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDD 114

  Fly    98 YGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFP 162
            |||::.:.|||:.:|:|||||::|.||.:| ...||..::|.|.|.|..||.|||||.::|.:||
  Rat   115 YGGIKIIRVPSDSLWIPDIVLFDNADGRFE-GASTKTVVRYNGTVTWTQPANYKSSCTIDVTFFP 178

  Fly   163 YDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEE---- 223
            :|.|.|.||||||||:|:|||:...||         .:|.|:|:.:.||:|:....:|...
  Rat   179 FDLQNCSMKFGSWTYDGSQVDIILEDQ---------DVDRTDFFDNGEWEIMSAMGSKGNRTDSC 234

  Fly   224 -YYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSL 287
             :||       .||:...::|..||||:.||:||:.|:||||:||||||:.|||::||.|:||||
  Rat   235 CWYP-------YITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPSNEGEKISLCTSVLVSL 292

  Fly   288 TVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHN-MSPLVRKLFL 351
            |||.|::.||||.:|..:||:|:||:||||.|:||:..||..:|||.||.|||| |:|.|||:||
  Rat   293 TVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPWVRKIFL 357

  Fly   352 HFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDVRDSISD-FPSEFKDSQDGAYDNGMQNSVDSD 415
            |.:|||:.||                          |.:| :.::.::::.||.... :|::::
  Rat   358 HKLPKLLCMR--------------------------SHADRYFTQREEAESGAGPKS-RNTLEA- 394

  Fly   416 NVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAII 480
                         ||..:|:|.:|:...:...|:||||||::.||||.|||.|.|..:.|||.:.
  Rat   395 -------------ALDCIRYITRHVVKENDVREVVEDWKFIAQVLDRMFLWTFLLVSIIGTLGLF 446

  Fly   481 CQSPSLY 487
            .  |.:|
  Rat   447 V--PVIY 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	195/452 (43%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	92/218 (42%)
Chrna5	NP_058774.2	LIC	41..448	CDD:273305	195/457 (43%)
		Neur_chan_LBD	47..250	CDD:280998	92/216 (43%)
		Neur_chan_memb	257..446	CDD:280999	99/229 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I1995
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830