DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta2 and Chrna3

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_434692.2	Gene:	Chrna3 / 25101	RGDID:	2345	Length:	499	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	226/505 - (44%)
Similarity:	323/505 - (63%)	Gaps:	54/505 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVN 70
            |:.|.:|:|.|:::     ||.   .||:..|..:||.:||||.|.:..:.:...:.:|||::|:
  Rat    13 LMLVLMLLPAASAS-----EAE---HRLFQYLFEDYNEIIRPVANVSHPVIIQFEVSMSQLVKVD 69

  Fly    71 LKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKAT 135
            ..||:|.||||:||.|.||||:|.|.:|.|||.:.||:|.||.||||||||.||:::|...|||.
  Rat    70 EVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKAL 134

  Fly   136 LKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGI 200
            |||||||.|.||||:||||:::|.|||:|.|.|.||||||:|:.|::||.         |:...:
  Rat   135 LKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLV---------LIGSSM 190

  Fly   201 DLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVL 265
            :|.:::.|.||.|::.|..|:|..|....|.:.|||:.|.:||..||||:|||:||:.::|||||
  Rat   191 NLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVL 255

  Fly   266 VFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVL 330
            |||||||.|||||||||:|:|||||.|::.|.||.|||.:||:|:|||||||.|:||:..||.||
  Rat   256 VFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVL 320

  Fly   331 NIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRR-------TQYTLPDY-------------DDSTP 375
            |:|:|:|:||.|...|:.:||:.:|::|.|.|       |..|...|             |..:.
  Rat   321 NVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSGEGDTPKTRTFYGAELSNLNCFSRADSKSC 385

  Fly   376 SNGYTNEIDV-------RDSISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRN-LTPEVLQALRA 432
            ..||..:...       |..||:|.:....|..       ..|||:  |:..: |:||:.:|:::
  Rat   386 KEGYPCQDGTCGYCHHRRVKISNFSANLTRSSS-------SESVDA--VLSLSALSPEIKEAIQS 441

  Fly   433 VRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQ 482
            |::||:::|..:...||.:|||:|:||:||.|||:|.|.|:.||..:..|
  Rat   442 VKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFLQ 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	224/497 (45%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	103/217 (47%)
Chrna3	NP_434692.2	LIC	24..490	CDD:273305	220/491 (45%)
		Neur_chan_LBD	29..235	CDD:280998	103/217 (47%)
		Neur_chan_memb	242..489	CDD:280999	110/255 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I1995
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	477	1.000	Inparanoid score	I1422
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm12327
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	1	1.100	-	-	LDO	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880