Protein Alignment nAChRbeta2 and pbo-6

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001294833.1
• Gene: pbo-6 / 24104421
• WormBaseID: WBGene00017375
• Length: 422
• Species: Caenorhabditis elegans
• Alignment Length: 502
• Identity: 117/502 - (23%)
• Similarity: 207/502 - (41%)
• Gaps: 131/502 - (26%)

  Fly     5 SLLCVFLLVPLAN-STAPISFEANPDTKRLYDDLLSNYNRLIRP-----VVNNTETLTVWLGLKL 63
            |.|.:|:.:.... ..|..|.:....:.||...||..:|:...|     :.:|.|         |
 Worm     4 SFLTIFIFITTVTVGVAEFSEQYQGSSSRLTRHLLEKHNKCSPPDGRVDISHNIE---------L 59

  Fly    64 SQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEV 128
            ..:|.:|..||.|...:::.|:|.|..|.|..||:.|::..::|...||:|||:::|    ..|.
 Worm    60 VHIIGINELNQNMQVLVYIVQQWTDASLSWKVEEFRGIKHTWLPEHSIWIPDIIVFN----TLEH 120

  Fly   129 TLMTKAT-----LKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDL---- 184
            .::.:|.     :.|||||.:..||||...|::.:..||:|:|:|.::|.||.|:..::.|
 Worm   121 KMLLEAVRSPIKVSYTGEVTYAYPAIYTVLCQIGIATFPFDDQVCKIRFASWAYDEDKILLNASH 185

  Fly   185 KHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYT 249
            |.|              |..:..:.||.:.:|...:.|..:.:|:  .|:|.:.:.:.||..:|.
 Worm   186 KPL--------------LKNYSPNEEWALQDVDMARKEYEHEETV--VSEIIYYIKVARKPFYYL 234

  Fly   250 VNLIVPCVALTFLTV----LVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGK 310
            ::|:||...:..|::    ..|....:..|:.||.::.::|:.|..|::.|.:|.:|..||||..
 Worm   235 ISLVVPSYIICVLSIAGLFARFSTKHERQERFTLGVTAILSMAVLSLVVTEKVPHSSENVPLLIV 299

  Fly   311 YLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTP 375
            |:.|.:::|:::...|..|:.:|.:...||.:||
 Worm   300 YMHFIIVMVTIATILTSTVMRVHAKGFRTHFLSP------------------------------- 333

  Fly   376 SNGYTNEIDVRDSISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHI 440
                                                       |..:...:|.|.:...|..||.
 Worm   334 -------------------------------------------PNWIRKVLLIARKHANFFQQHG 355

  Fly   441 KDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLY 487
            |.....:...|.|..||..:|      :.|:.||   .||..:|:||
 Worm   356 KVYMDIHTTAEQWGEVSRRMD------YLLASVF---IIIISTPTLY 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	110/488 (23%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	63/231 (27%)
		Cys-loop	154..168	CDD:349832	5/13 (38%)
pbo-6	NP_001294833.1	Neur_chan_LBD	31..230	CDD:460752	62/227 (27%)
		LGIC_TM_cation	231..>322	CDD:349853	24/90 (27%)
		TM1 helix	231..259	CDD:349853	6/27 (22%)
		TM2 helix	267..288	CDD:349853	6/20 (30%)
		TM3 helix	299..321	CDD:349853	5/21 (24%)