Protein Alignment nAChRbeta2 and HTR3D

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_054201603.1
• Gene: HTR3D / 200909
• HGNCID: 24004
• Length: 456
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 106/500 - (21%)
• Similarity: 186/500 - (37%)
• Gaps: 115/500 - (23%)

  Fly    21 PISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLT-VWLGLKLSQLIEVNLKNQVMTTNLWVKQ 84
            |.:|:|..|.|.:  ..::||:  :...||.:.||: :|           |..:::.|.|....:
Human    41 PAAFQAVFDRKAI--GPVTNYS--VATHVNISFTLSAIW-----------NCYSRIHTFNCHHAR 90

  Fly    85 RWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWD----GNYEVTLMTKATLKYTGEVFWE 145
            .|.:..::|:|:|.||:::..:.:|::|:.|:.:..:.|    |......:.|||.....:..|.
Human    91 PWHNQFVQWNPDECGGIKKSGMATENLWLSDVFIEESVDQTPAGLMASMSIVKATSNTISQCGWS 155

  Fly   146 PPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVE 210
            ..|.:..|...:::.         .:..:|........:.|               .|.|....|
Human   156 ASANWTPSISPSMDR---------AEPRAWRRMSRSFQIHH---------------RTSFRTRRE 196

  Fly   211 WDIL-------EVPATKNEEYYPDTLEPFSDITFKLTMRR--KTLFYTVNLIVPCVALTFLTVLV 266
            |.:|       :|....|:         :....|.:.:|.  :...|.||.:||...|..:..|.
Human   197 WVLLGIQKRTIKVTVATNQ---------YEQAIFHVAIRHRCRPSPYVVNFLVPSGILIAIDALS 252

  Fly   267 FYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPT------SLAVPL--------LGKYLLFTMI 317
            ||||.:||......:::|:..:||.|::.:::|.|      ||..||        .|.|....:.
Human   253 FYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVAPLALMQTPLPAGVYFALCLS 317

  Fly   318 LVSLSVWTTVCVLNIHFRSPSTHNMSPLVR---KLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGY 379
            |:..|:..|:.:  .|....:|....||.|   .|.||...:    .|...|.|...:..|  |.
Human   318 LMVGSLLETIFI--THLLHVATTQPLPLPRWLHSLLLHCTGQ----GRCCPTAPQKGNKGP--GL 374

  Fly   380 TNEIDVRDSISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDAD 444
            |            |:...         |::....|...:|.....|:.......|  ||...:|.
Human   375 T------------PTHLP---------GVKEPEVSAGQMPGPGEAELTGGSEWTR--AQREHEAQ 416

  Fly   445 KDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDT 489
            |.:. ||.|...|..:|.....|:.|......:.:||    |::|
Human   417 KQHS-VELWVQFSHAMDALLFHLYLLFMASSIITVIC----LWNT 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	102/488 (21%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	40/231 (17%)
		Cys-loop	154..168	CDD:349832	0/13 (0%)
HTR3D	XP_054201603.1	LGIC_ECD	30..228	CDD:475126	43/234 (18%)
		LGIC_TM_5-HT3	232..455	CDD:349865	62/258 (24%)
		TM1 helix	232..256	CDD:349865	9/23 (39%)
		TM2 helix	264..285	CDD:349865	4/20 (20%)
		TM3 helix	310..332	CDD:349865	4/23 (17%)
		TM4 helix	430..452	CDD:349865	3/21 (14%)