Protein Alignment nAChRbeta2 and acr-14

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_495716.1
• Gene: acr-14 / 191601
• WormBaseID: WBGene00000053
• Length: 500
• Species: Caenorhabditis elegans
• Alignment Length: 516
• Identity: 148/516 - (28%)
• Similarity: 258/516 - (50%)
• Gaps: 74/516 - (14%)

  Fly    10 FLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQ 74
            |:|:     |..|..:.:.|..||...|..||:...|||.|::..|.|.:...|:|:::|:.|||
 Worm     6 FILL-----TFYIQVKGSVDEYRLLQYLKENYDSFERPVENSSAPLDVKVRFLLNQIMDVDEKNQ 65

  Fly    75 VMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSE-----HIWVPDIVLYNNWDGNYEVTLMTKA 134
            ||:...::...|.||||.|||:.:||:..:....:     .:|.||::|:|:...:::.|..::.
 Worm    66 VMSILAYMDYHWNDYKLTWDPKLFGGIRDVRFSGDDDASFKLWRPDVLLFNSVSESFDSTYSSRF 130

  Fly   135 TLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKH-LDQIPG------ 192
            .:...|:|...||.|::..|:::|.|:|:|:|.||:|.|||||||..::|.. |.||.|
 Worm   131 IVSSNGDVQQNPPGIFRFVCQIDVTYYPFDKQTCFLKLGSWTYNGQYINLDFLLTQIIGLHGIPI 195

  Fly   193 ------------SNLVQVGIDLTEFYLSVEWDILEVPATK------NEEYYPDTLEPFSDITFKL 239
                        |..|...|||..:..:.|||:...|..:      .:||:        ::.|.:
 Worm   196 VVEPERSSTNYASYFVNESIDLQVYLQNGEWDLEGTPGKRVVQKFGTDEYH--------ELYFYI 252

  Fly   240 TMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLA 304
            .:||:||.|.:|||:|.:.::.:|:|.|.||.|:.||:||..::|:|:..|..:::...||.|.:
 Worm   253 HIRRRTLAYGINLIIPSLVISMMTILGFTLPPDACEKITLETTVLLSVIFFLQMVSSTSPPQSQS 317

  Fly   305 VPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPD 369
            ||:|..:....::||:.|...||..|::|.|.|.||.|||.:||:|:.::|.::.|.:     ||
 Worm   318 VPILAAFFSCCLMLVACSCVFTVLTLSLHHRKPETHEMSPTMRKIFIDWLPYILCMCK-----PD 377

  Fly   370 YDDSTPSNGYTNEIDVRDSISDFP---------SEFKDSQDGAYDNGMQNSVDSDNVIP------ 419
            :..:.........|.....:|..|         :.|.|.....|           :.:|
 Worm   378 HPKTPKPKVLGKSIAPIHRLSTIPMLNLPRVSQTTFPDKNVFVY-----------HEVPAVIKNT 431

  Fly   420 RNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAII 480
            ..:..|:|...|.:..:...|::..|::.:..:|:|.:|.:||..|::|:......|..:|
 Worm   432 SRICAELLIIERDIEKMLDKIEEDTKEDMLRSEWRFAAMAVDRLCLYVFSAFITMITCGLI 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	147/513 (29%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	77/247 (31%)
		Cys-loop	154..168	CDD:349832	6/13 (46%)
acr-14	NP_495716.1	Neur_chan_LBD	21..258	CDD:460752	75/244 (31%)
		Neur_chan_memb	265..491	CDD:460753	63/241 (26%)