Protein Alignment nAChRbeta2 and lev-8

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_509932.2
• Gene: lev-8 / 191600
• WormBaseID: WBGene00002975
• Length: 531
• Species: Caenorhabditis elegans
• Alignment Length: 539
• Identity: 180/539 - (33%)
• Similarity: 308/539 - (57%)
• Gaps: 55/539 - (10%)

  Fly     1 MW------HWSLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWL 59
            ||      |..||.:|:|       ..::..||....:|.::||::||:.:|||.|.::.|.|..
 Worm     1 MWIPQRISHIFLLVIFIL-------HIVTINANKHVSQLLENLLTDYNKAVRPVHNASDALKVKF 58

  Fly    60 GLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDG 124
            |..|.:||:|:..|||:||:||::.:|:|.||.|:|.::||||.:::||:.||:||||||||.||
 Worm    59 GANLCRLIDVDEVNQVLTTSLWLEMQWYDKKLTWNPTDWGGVEYIHIPSDQIWIPDIVLYNNADG 123

  Fly   125 NYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHL-- 187
            ...:|:.:.|.:.:.|.|.|:||:||||.|.:|::|||||.|.|.||||.|:.:|..:||..:
 Worm   124 EPHITITSLAKIDHHGRVVWQPPSIYKSFCPINIKYFPYDWQTCEMKFGGWSNDGETLDLYQIPV 188

  Fly   188 --DQIPGSN---------LVQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTL--EPFSDITFKL 239
              |.||...         .::.|:.|:.::.|.|||:|...:::..:.||...  :.:.||.:::
 Worm   189 DVDDIPQVKRQDDGVEFLYLEKGLGLSFYHESAEWDLLSATSSRYAQIYPGCCGQQYYIDIKYRI 253

  Fly   240 TMRRKTLFYTVNLIVPCVALTFLTVLVF-YLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSL 303
            .:|||.:|:||.|.:||:.:..:|..|| .||::  .|:|..||:||:.:||:|:|.::||||||
 Worm   254 IIRRKAIFFTVTLTIPCMLIANVTPFVFLILPNE--HKMTYSISVLVAFSVFYLVLIDLIPPTSL 316

  Fly   304 AVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLP 368
            ::.|:|.|||||:::||:|:..:|..:|::.:...:..||...|.||:..:|||:.::..::||.
 Worm   317 SLSLIGIYLLFTLLMVSVSIILSVVTINMYRKQAFSSGMSHWQRWLFVQRLPKLLRLKTLEHTLG 381

  Fly   369 DYDDSTPSNGYTNEIDVRDSISD-----------FPSEFKDSQDGAYDNGMQNSVDSDNVIPRNL 422
            ..:.|..:...|..:.|..|::.           ||.:         ...:.:.|..|..:.:..
 Worm   382 PDEGSETTTPRTGSVSVTASVTQRTLNPNNNSPVFPPQ---------RLRLLSLVQMDEALKQRC 437

  Fly   423 TPEVLQALRAV----RFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQS 483
            ..:.|...|.:    :.|:.|..:...:.:|.|:|:.:|:|:||.||.||....:...:..:..|
 Worm   438 AADNLDLFRKIAGHLKIISAHFHNQQMEGKITEEWQLMSLVIDRIFLILFLAVSMAANIMFVYNS 502

  Fly   484 PSLYDTRSPIDRQLSEIPL 502
            |:|:|.|..:...::..||
 Worm   503 PTLFDDRPSLVPSVAHKPL 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	168/500 (34%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	92/232 (40%)
lev-8	NP_509932.2	LIC	10..499	CDD:273305	170/506 (34%)
		Neur_chan_LBD	30..258	CDD:280998	90/227 (40%)
		Neur_chan_memb	268..497	CDD:280999	68/239 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920