Protein Alignment nAChRbeta2 and acr-10

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_508692.3
• Gene: acr-10 / 191598
• WormBaseID: WBGene00000049
• Length: 557
• Species: Caenorhabditis elegans
• Alignment Length: 572
• Identity: 173/572 - (30%)
• Similarity: 278/572 - (48%)
• Gaps: 129/572 - (22%)

  Fly     6 LLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVN 70
            :||:|.::    |...|..|.:....:||.|:|..|.:|.|||......|.|.:.:.|.|::.::
 Worm     7 VLCLFFIL----SLIIIESECSKAENKLYRDILQGYLKLARPVRYPRNVLKVHMKVFLQQILNLD 67

  Fly    71 LKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQL-YVPSEH-IWVPDIVLYNNWDGNYEVTLMTK 133
            .:||::..|.|:|..|.||:|:|||.:|..:..: :...|: ||.|||:|||:...:::.:..:.
 Worm    68 GQNQIIEVNAWLKYVWMDYRLQWDPLQYDNITSIRFAGGENQIWRPDILLYNSASEDFDSSFKSN 132

  Fly   134 ATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQV 198
            ..:..||||.|.||.|:::||:|::.|||:|:|:|::|||||||:|..:||..:.:...|.|
 Worm   133 EVVYNTGEVNWIPPGIFRASCKMDITYFPFDDQVCYLKFGSWTYHGLALDLSIIAEEDDSEL--- 194

  Fly   199 GIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLT 263
            .|||:.:..|.||.:.:.||.|:.:|.....||:|.:||.:.:||:||||..|:|:|.:.::.:|
 Worm   195 SIDLSTYTPSGEWHLTKAPAVKDVKYNSCCKEPYSTVTFYMFLRRRTLFYLFNIILPSLLISIMT 259

  Fly   264 VLVFYLPS-DSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTV 327
            ::.|.||: |..||:....:||:|:..|..:::|:.||||.:|||||.:.....::.|:|...|:
 Worm   260 LMGFCLPAHDMSEKIGYQTTILLSICFFVTIVSEMTPPTSESVPLLGMFFSSLTLISSVSTAFTI 324

  Fly   328 CVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNE---IDVRDSI 389
            .|||..:|.....:|.|:..|:||.::|.|::|:|            |...|...   :..|:.|
 Worm   325 TVLNFRYRQVQNIHMHPIFYKVFLIWIPWLLLMKR------------PGVFYKKRRATVQAREEI 377

  Fly   390 SDF----------PSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVL----------------- 427
            |.|          |.||..|.          |:||.:.:|....|:.|
 Worm   378 SFFDNGDDDCCPKPPEFDYSL----------SIDSADTLPLPPRPKPLLKKMHSVPAEHLHLDRK 432

  Fly   428 ----------------------QALRAVRF------IAQHIKDA--------------------- 443
                                  .:||:.||      |.:.|.||
 Worm   433 VGDGILKSQRRPLVLTKNVNKSHSLRSRRFTQFEKYIKKCIDDAKLRKNSTYSTYSMMIITYYRQ 497

  Fly   444 ------------DKDNEIV---EDWKFVSMVLDRFFLWLFTL---SCVFGTL 477
                        ||..:.:   |||||.:|.|||..|.|.||   .|:||.:
 Worm   498 IDEMLKLLNRRLDKQRKYLFKQEDWKFAAMALDRLCLLLITLLIVMCLFGMI 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	171/569 (30%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	82/219 (37%)
acr-10	NP_508692.3	Neur_chan_LBD	27..241	CDD:280998	81/216 (38%)
		Neur_chan_memb	248..>361	CDD:280999	39/124 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910