Protein Alignment nAChRbeta2 and acr-10

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_508692.3
• Gene: acr-10 / 191598
• WormBaseID: WBGene00000049
• Length: 557
• Species: Caenorhabditis elegans
• Alignment Length: 572
• Identity: 173/572 - (30%)
• Similarity: 278/572 - (48%)
• Gaps: 129/572 - (22%)

  Fly     6 LLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVN 70
            :||:|.::    |...|..|.:....:||.|:|..|.:|.|||......|.|.:.:.|.|::.::
 Worm     7 VLCLFFIL----SLIIIESECSKAENKLYRDILQGYLKLARPVRYPRNVLKVHMKVFLQQILNLD 67

  Fly    71 LKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQL-YVPSEH-IWVPDIVLYNNWDGNYEVTLMTK 133
            .:||::..|.|:|..|.||:|:|||.:|..:..: :...|: ||.|||:|||:...:::.:..:.
 Worm    68 GQNQIIEVNAWLKYVWMDYRLQWDPLQYDNITSIRFAGGENQIWRPDILLYNSASEDFDSSFKSN 132

  Fly   134 ATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQV 198
            ..:..||||.|.||.|:::||:|::.|||:|:|:|::|||||||:|..:||..:.:...|.|
 Worm   133 EVVYNTGEVNWIPPGIFRASCKMDITYFPFDDQVCYLKFGSWTYHGLALDLSIIAEEDDSEL--- 194

  Fly   199 GIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLT 263
            .|||:.:..|.||.:.:.||.|:.:|.....||:|.:||.:.:||:||||..|:|:|.:.::.:|
 Worm   195 SIDLSTYTPSGEWHLTKAPAVKDVKYNSCCKEPYSTVTFYMFLRRRTLFYLFNIILPSLLISIMT 259

  Fly   264 VLVFYLPS-DSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTV 327
            ::.|.||: |..||:....:||:|:..|..:::|:.||||.:|||||.:.....::.|:|...|:
 Worm   260 LMGFCLPAHDMSEKIGYQTTILLSICFFVTIVSEMTPPTSESVPLLGMFFSSLTLISSVSTAFTI 324

  Fly   328 CVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNE---IDVRDSI 389
            .|||..:|.....:|.|:..|:||.::|.|::|:|            |...|...   :..|:.|
 Worm   325 TVLNFRYRQVQNIHMHPIFYKVFLIWIPWLLLMKR------------PGVFYKKRRATVQAREEI 377

  Fly   390 SDF----------PSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVL----------------- 427
            |.|          |.||..|.          |:||.:.:|....|:.|
 Worm   378 SFFDNGDDDCCPKPPEFDYSL----------SIDSADTLPLPPRPKPLLKKMHSVPAEHLHLDRK 432

  Fly   428 ----------------------QALRAVRF------IAQHIKDA--------------------- 443
                                  .:||:.||      |.:.|.||
 Worm   433 VGDGILKSQRRPLVLTKNVNKSHSLRSRRFTQFEKYIKKCIDDAKLRKNSTYSTYSMMIITYYRQ 497

  Fly   444 ------------DKDNEIV---EDWKFVSMVLDRFFLWLFTL---SCVFGTL 477
                        ||..:.:   |||||.:|.|||..|.|.||   .|:||.:
 Worm   498 IDEMLKLLNRRLDKQRKYLFKQEDWKFAAMALDRLCLLLITLLIVMCLFGMI 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	171/569 (30%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	82/219 (37%)
		Cys-loop	154..168	CDD:349832	7/13 (54%)
acr-10	NP_508692.3	LGIC_ECD_nAChR	52..240	CDD:349798	71/190 (37%)
		Cys-loop	153..167	CDD:349798	7/13 (54%)
		LGIC_TM_cation	242..>332	CDD:349853	33/89 (37%)
		TM1 helix	242..266	CDD:349853	8/23 (35%)
		TM2 helix	275..296	CDD:349853	5/20 (25%)
		TM3 helix	307..329	CDD:349853	5/21 (24%)