DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta2 and acr-5

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001367477.1	Gene:	acr-5 / 191596	WormBaseID:	WBGene00000044	Length:	598	Species:	Caenorhabditis elegans

Alignment Length:	496	Identity:	136/496 - (27%)
Similarity:	230/496 - (46%)	Gaps:	67/496 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DTKRLYDDLL--SNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKL 91
            |.:||.::||  :.|.:.:.|..:.|....|.|.:.|.|:::|:...|.:..|:|:.|.|:|..|
Worm   103 DQRRLVEELLDPNYYEKTVHPKRDYTRPTRVNLSMSLYQILDVDEHMQSIEVNVWMVQHWYDEFL 167

  Fly    92 RWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVT-LMTKATLKYTGEVFWEP--------- 146
            .|:|.:||.:.:..||...||:||..|||:.:...:.| .:..|.|: ||.  |..
Worm   168 DWNPVDYGMINRTIVPYHQIWIPDTYLYNSEELEQKKTESLMNAQLE-TGH--WNQKKDGAKVQL 229

  Fly   147 --PAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSV 209
              |||||.||.|:|.:||||.|.|.....|||:     |.:.:|..|.|:.|.:|    ....:.
Worm   230 MFPAIYKLSCRMDVRWFPYDRQNCTFIISSWTH-----DKQTIDYWPLSSTVNLG----NMARND 285

  Fly   210 EWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSG 274
            ||:::.....:.||.:.....|:..:...|.:|||.|:|.:||:||...:|.:.|..|:.|:.|.
Worm   286 EWEVISFEFVRVEETFKCCTAPWVMLYAHLVIRRKPLYYMINLVVPTSIITIVAVTGFFTPTSSS 350

  Fly   275 ----EKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFR 335
                ||:.|.|:.|::::|..|::...:|.||..|||:..|.:..::::.:..:....||.||.:
Worm   351 SERDEKLYLGINTLLTMSVMMLMVCNQMPSTSTYVPLMSWYYIGIIMVIVVGTFLATGVLAIHGQ 415

  Fly   336 SPSTHNMSPLVRKL--------FLHFMPKLMMMRRTQY-TLPDYDDSTPSN----------GYTN 381
            ......:|..:|||        |:...|..::...|:: .:.:...||..:          .:|.
Worm   416 KHYNKPISDRIRKLIYNPVVEFFILSPPTSLIDLWTEFGVISEQRHSTHLDPLLLQHMDPISHTT 480

  Fly   382 EIDVRDSISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEV-LQALRAVRF-------IAQ 438
            ..|.:.......|:..|.| ..|....:.:     .|.|..|... ::|||..::       .|:
Worm   481 RADPQHFFGSISSQMCDLQ-STYSYTARLA-----TITRQYTQHAKMKALRKNQYRMSMDTSQAR 539

  Fly   439 HIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAI 479
            .:|..........:|:|::.||||..|.:|   |.| |.|:
Worm   540 GVKKQKMQRRCSLEWEFLANVLDRILLTIF---CGF-TFAV 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	135/494 (27%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	72/231 (31%)
acr-5	NP_001367477.1	LIC	104..581	CDD:273305	135/495 (27%)
acr-5	NP_001367477.1	Neur_chan_LBD	104..321	CDD:397192	70/228 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910