Protein Alignment nAChRbeta2 and acr-6

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_491354.2
• Gene: acr-6 / 191479
• WormBaseID: WBGene00000045
• Length: 551
• Species: Caenorhabditis elegans
• Alignment Length: 556
• Identity: 200/556 - (35%)
• Similarity: 314/556 - (56%)
• Gaps: 81/556 - (14%)

  Fly     9 VFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKN 73
            :|.|:.|..|....||.|   .|.|::.||:.||::..|......|||:...|:|.|:::|:.|:
 Worm     2 LFRLILLLFSIRLCSFTA---YKSLFETLLARYNKIAFPSGEFNNTLTIEFKLRLDQIVDVHEKD 63

  Fly    74 QVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKY 138
            ||:|....:...|.||:|.|:|:|:|.:..::.|.|.:|:|||:||||..|:..|:..|:..:.:
 Worm    64 QVITLKGTLIHHWLDYRLSWNPDEFGNITLMHFPGEMLWLPDIILYNNAHGSPWVSETTQVHVSF 128

  Fly   139 TGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHL--DQ------IPGSNL 195
            .|.|.|:||.:|.:.|.:::|::|||.|||.:|||||||.|:|::|.||  ||      ..|.|:
 Worm   129 EGRVTWQPPVVYDAFCNIDIEWYPYDLQICELKFGSWTYGGSQLNLIHLTTDQANESTDATGDNV 193

  Fly   196 --VQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVA 258
              |:.|:||:.:..|||||:|.|...:::::||....|..|||:.|.:|||.||||||:|:|||.
 Worm   194 WKVERGVDLSNYQESVEWDLLSVEGIRHKKWYPCCDYPSIDITYYLHIRRKKLFYTVNMIIPCVC 258

  Fly   259 LTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSV 323
            |..:|:.|||||.:|.:|:.||||:||:||::||:|.:||||||:..||:.|||.||||:|:|||
 Worm   259 LASMTLWVFYLPCESHQKIQLCISVLVALTLYFLMLIDIIPPTSIVTPLILKYLSFTMIMVALSV 323

  Fly   324 WTTVCVLNIHFRS---PSTHNMSPLVRKLFLHFM-PKLMMMRRT--------------------- 363
            ..||.:.|||:|:   |    |...|:..|:..: .||::.|:|
 Worm   324 TCTVFIQNIHYRAYYQP----MPRFVKHWFIEKLGKKLLISRKTEQAQYHRTAQHVKQVNALSAM 384

  Fly   364 -------QYTLPDYDDSTPS-----------NGYTNEIDVRD-SISDFPSEFKDSQDGAYDNGMQ 409
                   |.||.:.:.:|.:           |....|:.:.: |:|   .:.:.....|..|.|:
 Worm   385 NILEKQFQKTLFELEIATMAKKTVTAAPKTVNSIFLELPMMNRSVS---VKIRKPSVKAVKNRMR 446

  Fly   410 N--SVDSDNVI----PRNLTPE-----------VLQALRAVRFIAQHIKDADKDNEIVEDWKFVS 457
            .  |:|..:.|    ...::||           :.:|.:.:.|||:.:.|..:..|...||:|||
 Worm   447 RLLSIDMTDDIRGKETEEISPETTKDTDPDREKLRKAEKNIHFIAKTLTDERRAQEAEADWQFVS 511

  Fly   458 MVLDRFFLWLFTLSCVFGTLAIICQSPSLYDTRSPI 493
            :|:||..|.:|:.:...||:..|..:|::.|.|.||
 Worm   512 LVIDRMLLIIFSFTITIGTILTIFSAPTMRDNREPI 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	194/540 (36%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	90/227 (40%)
		Cys-loop	154..168	CDD:349832	6/13 (46%)
acr-6	NP_491354.2	LGIC_ECD	21..247	CDD:475126	90/225 (40%)
		LGIC_TM_nAChR	246..>335	CDD:349866	54/88 (61%)
		TM1 helix	246..270	CDD:349866	15/23 (65%)
		Neur_chan_memb	252..524	CDD:460753	89/278 (32%)
		TM2 helix	278..299	CDD:349866	12/20 (60%)
		TM3 helix	310..332	CDD:349866	13/21 (62%)