Protein Alignment nAChRbeta2 and acr-24

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001255865.1
• Gene: acr-24 / 190686
• WormBaseID: WBGene00013534
• Length: 578
• Species: Caenorhabditis elegans
• Alignment Length: 539
• Identity: 135/539 - (25%)
• Similarity: 238/539 - (44%)
• Gaps: 106/539 - (19%)

  Fly    32 RLYDDLLS--NYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWD 94
            ||..||..  .|:..:|||:|:::..||...:.|.|::.:|.|.|.:..|:|..|:|.|..|.|:
 Worm    34 RLAKDLTDPRRYDSRVRPVMNHSKPTTVSFSMSLYQILSINEKQQNVDLNVWAIQKWNDDFLGWN 98

  Fly    95 PEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVT---LMTKATLKY----TG-EVFWEPPAIYK 151
            |..||.:....:|.:.||:||..|||:...|.|.|   :....|..|    || ||.:..||:|:
 Worm    99 PYLYGMINTTILPFDAIWLPDTYLYNSVVMNREETERYINVVVTTNYWKGETGAEVKFMYPALYR 163

  Fly   152 SSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEV 216
            :||.:::.:||||:|.|.:...|||.:.:.::.:...:         .:::..|..:.||.::..
 Worm   164 TSCLLDIRFFPYDQQACKLTISSWTSSKSDINYEPEHE---------SVNMDNFLPNEEWVVVSF 219

  Fly   217 PATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFY----LPSDSGEKV 277
            ...:.||.:....||:..:...|.:|||.|:|.|||::|...:|.:.|..|:    ..|:..||:
 Worm   220 NIKRVEEKFVCCPEPWVLLEAVLVVRRKPLYYIVNLVIPTSVITLVAVTGFFTAASTSSERREKL 284

  Fly   278 TLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNM 342
            :|.|..|:::::..::::|.:|.:|..|||.|.:.|..:.::.:....|..:||:|.:......:
 Worm   285 SLGIDSLLAMSILMMMVSEQMPTSSDFVPLFGIFYLSIIFIIFIGTLFTAFILNVHLQKMYAKPV 349

  Fly   343 SPLVRKLF-------LHFMPKLMMM--------------RRTQYTLPDYDDSTP----------- 375
            ||:|..:|       |...|..|::              ::...|:|......|
 Worm   350 SPIVSYIFFGRIAQWLRMRPPTMLLELWNETGVTFGKEGQKNSKTIPKNHKMIPKVTSSSSGLHL 414

  Fly   376 --SNGYTNE------IDVRDSIS--DFPSEF-------------KDSQDGAY-----DNGMQNSV 412
              ||..:..      |..|..||  |...|.             .:.|:|..     :.|.....
 Worm   415 LKSNSGSGRAPLAAPISARSYISMDDMKREAARRNWRRLVAKINSNKQNGVKIVGGGERGQLRQA 479

  Fly   413 DSDNVIPRNLT-------PEVLQALRAVRFIAQHIKDADKDNEIVE---------DWKFVSMVLD 461
            :...:.|..::       |.:|.|.....|      ....|:.|:|         :|::::.|||
 Worm   480 NRKKMAPSAISVPHGEPGPLMLSASAISAF------SVTGDSTILESKLKRRYALEWEYLASVLD 538

  Fly   462 RFFLWLFTLSCVFGTLAII 480
            |..|.:|:| .||...:|:
 Worm   539 RVLLIVFSL-VVFAVTSIM 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	134/536 (25%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	68/224 (30%)
acr-24	NP_001255865.1	Neur_chan_LBD	34..248	CDD:280998	67/222 (30%)
		Neur_chan_memb	255..>411	CDD:280999	33/155 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010